Hopp til hovedinnhold

Myelodysplastiske syndromer

Myelodysplastisk syndrom omfatter en rekke tilstander med skader på "morcellene" (stamcellene) i beinmargen. Sykdommen er ofte uten symptomer i lengre tid, men etter hvert vil det utvikles symptomer fra en eller flere av celletypene som er påvirket.

Sist revidert:

QR
Del pasientinformasjon

Den ligger åpent tilgjengelig på NHI.no sammen annen relevant informasjon

https://nhi.no/sykdommer/blod/beinmargssykdommer/myelodysplastisk-syndrom/ 

Hva er myelodysplastisk syndrom?

Årsaker

Diagnosen

Behandling

Prognose

Pasientorganisasjon

Vil du vite mer?

Kilder

Referanser

Dette dokumentet er basert på det profesjonelle dokumentet Myelodysplastiske syndromer. Referanselisten for dette dokumentet vises nedenfor.

  1. Nasjonalt handlingsprogram med retningslinjer for diagnostikk, behandling og oppfølging av maligne blodsykdommer. Myelodysplastiske syndromer. Helsedirektoratet 27.05.2020. www.helsedirektoratet.no 
  2. Nordic MDS Group. Guidelines for the diagnosis and treatment of Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia. 8th update, May 2017 www.nmds.org 
  3. Steensma DP. Myelodysplastic syndromes current treatment algorithm 2018. Blood Cancer J. 2018;8(5):47. Published 2018 May 24. PMID: 29795386 PubMed 
  4. Besa EC. Myelodysplastic syndrome. Medscape, last updated Apr 10, 2020. emedicine.medscape.com 
  5. Germing U, Kobbe G, Haas R, Gattermann N. Myelodysplastic syndromes: diagnosis, prognosis, and treatment. Dtsch Arztebl Int. 2013 Nov 15. 110(46):783-90.
  6. Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 2016;127(20):2391-405. Blood 
  7. Molldrem JJ, Leifer E, Bahceci E et al. Antithymocyte globulin for treatment of the bone marrow failure asssociated with myelodysplastic syndromes. Ann Intern Med 2002;137:156-63. Annals of Internal Medicine 
  8. Musto P, Maurillo L, Spagnoli A, et al. Azacitidine for the treatment of lower risk myelodysplastic syndromes : a retrospective study of 74 patients enrolled in an Italian named patient program. Cancer 2010; 116: 1485. PubMed 
  9. van der Helm LH, Alhan C, Wijermans PW, et al. Platelet doubling after the first azacitidine cycle is a promising predictor for response in myelodysplastic syndromes (MDS), chronic myelomonocytic leukaemia (CMML) and acute myeloid leukaemia (AML) patients in the Dutch azacitidine compassionate named patient programme. Br J Haematol 2011; 155: 599-606. PubMed 
  10. Sauntharajah Y, Nakamura R, Nam J et al. HLA-DR15(DR2) is overrepresented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome. Blood 2002; 100:1570-4. PubMed 
  11. Greenberg P, Cox C, LeBeau MM, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997; 89: 2079. Blood 
  12. Nordic MDS Group. Guidelines for the diagnosis and treatment of Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia. 5 utg. Stockholm: Nordic MDS Group; 2011. www.nmds.org 
  13. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H et al., red. WHO classification of tumours of haematopoietic and lymphoid tissue. 4 utg. Lyon: IARC; 2008.