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Antifosfolipid syndrom

Sist oppdatert: Sist revidert:
Sist revidert av:


Definisjon:
Er en systemisk autoimmun sykdom karakterisert ved arterielle og venøse tromboser, svangerskapskomplikasjoner
Forekomst:
Prevalens er ukjent, men er beregnet å være ca. 0,5% i befolkningen
Symptomer:
Venøs trombose er det hyppigste debutsymptomet. Arterielle tromboser kan medføre hjerneslag og TIA hos yngre personer
Funn:
Forenlig med trombotisk sykdom eller svangerskapskomplikasjoner
Diagnostikk:
Utredes av spesialist med bl.a. undersøkelse på antistoff mot fosfolipider
Behandling:
Hovedbehandlingen er bruk av antitrombotiske medikamenter
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  7. Opatrny L, David M, Kahn SR, Shrier I, Rey E. Association between antiphospholipid antibodies and recurrent fetal loss in women without autoimmune disease: a metaanalysis. J Rheumatol 2006; 33: 2214-21. PubMed  
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  17. Pengo V, Denas G, Zoppelaro G, et al. Rivaroxaban vs warfarin in high-risk patients with antiphospholipid syndrome. Blood 2018. pmid:30002145 PubMed  
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  • Ingard Løge, spesialist allmennmedisin, redaktør NEL

Tidligere fagmedarbeidere

  • Odd Kildahl-Andersen, overlege, dr. med., Medisinsk avdeling, Universitetssykehuset Nord-Norge, Harstad sykehus
  • Bo Baslund, overlæge, klinisk lektor, Reumatologisk Klinik, Rigshospitalet
  • Hans Carl Hasselbalch, professor, overlæge, dr.med., Hæmatologisk afd., Roskilde Sygehus, Københavns Universitet