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Cushings syndrom

Sist oppdatert: Sist revidert:
Sist revidert av:
Definisjon:
Cushing syndrom er det kliniske bildet som er forårsaket av forhøyet kortisol. Cushings sykdom skyldes ACTH-produserende tumor (hypofyseadenom hyppigst). ACTH-uavhengig Cushing syndrom skyldes sykdom i binyrebark eller eksogen tilførsel av glukokortikoider
Forekomst:
Endogen Cushing sykdom er sjelden. 
Symptomer:
Typiske symptomer er vektøkning med sentral fedme, trettbarhet, amenoré, tynn hud, psykiske forandringer (depresjon)
Funn: 
Måneansikt, tyrenakke, trunkal fedme, hirsutisme, hudblødninger, striae, proksimal myopati, hypertensjon
Diagnostikk:
Fritt kortisol i spytt eller døgnurin. ACTH i plasma. 
Behandling:
Primært kirurgisk behandling
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  • Ingard Løge, spesialist allmennmedisin, redaktør NEL
  • Cecilia Mattsson, docent och överläkare, Endokrinsektionen, Medicinkliniken, Norrlands universitetssjukhus, Umeå (Medibas)

Tidligere fagmedarbeidere

  • John Cooper, spesialist i allmennmedisin og indremedisin, Medisinsk avdeling, Sentralsjukehuset i Rogaland, Stavanger
  • Stein Vaaler, overlege dr. med., Senter for Klinisk Epidemiologi, Rikshospitalet, Universitetet i Oslo