Hopp til hovedinnhold

Aortaaneurisme

Et aortaaneurisme er en avgrenset utvidelse av hele åreveggen i hovedpulsåren. Utvidelsen er minst dobbelt så vid som nærmeste normale del av blodåren.

Sist revidert:

QR
Del pasientinformasjon

Den ligger åpent tilgjengelig på NHI.no sammen annen relevant informasjon

https://nhi.no/sykdommer/hjertekar/blodaresykdom/hovedpulsaren-utposning/ 

Hva er et aortaaneurisme?

Årsaker

Diagnostikk

Behandling

Prognose

Vil du vite mer?

Kilder

Referanser

Dette dokumentet er basert på det profesjonelle dokumentet Aortaaneurismer. Referanselisten for dette dokumentet vises nedenfor.

  1. Erbel R, Aboyans V, Boileau C, et al. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases. Eur Heart J 2014; 35: 2873-2926. pmid:25173340 PubMed 
  2. Sakalihasan N, Limet R, Defawe OD. Abdominal aortic aneurysm. Lancet 2005; 365: 1577-89. PubMed 
  3. Kniemeyer HW, Kessler T, Reber PU, Ris HB, Hakki H and Widmer MK. Treatment of ruptured abdominal aortic aneurysm, a permanent challenge or a waste of resources? Prediction of outcome using a multi-organ-dysfunction score. Eur J Vasc Endovasc Surg 2000; 19: 190-6. PubMed 
  4. Wanhainen A, Verzini F, Herzeele IV, et al. Editor's Choice - European Society for Vascular Surgery (ESVS) 2019 Clinical Practice Guidelines on the Management of Abdominal Aorto-iliac Artery Aneurysms. Eur J Vasc Endovasc Surg 2019; 57: 8-93. pmid:30528142 PubMed 
  5. Frønsdal KB, Svensjö S, Movik E, et al. Abdominalt aortaaneurisme (AAA) screening av menn i alder 65 år. Folkehelseinstituttet 2020. www.fhi.no 
  6. Duncan JL, Harrild KA, Iversen L, et al. Long term outcomes in men screened for abdominal aortic aneurysm: prospective cohort study. BMJ 2012; 344: e2958. BMJ (DOI) 
  7. Detaint D, Michelena HI, Nkomo VT, et al. Aortic dilatation patterns and rates in adults with bicuspid aortic valves: a comparative stsudy with Marfan syndrome and degenerative aortopathy. Heart 2013. doi:10.1136/heartjnl-2013-304920 DOI 
  8. Wahlgren CM, Larsson E, Magnusson PK, et al. Genetic and environmental contributions to abdominal aortic aneurysm development in a twin population. J Vasc Surg 2010; 51: 3-7. pmid:19939604 PubMed 
  9. Singh S, Nautiyal A. Aortic Dissection and Aortic Aneurysms Associated with Fluoroquinolones: a Systematic Review and Meta-Analysis of Observational Studies. Am J Med 2017. pmid:28739200 PubMed 
  10. Newton ER, Akerman AW, Strassle PD, Kibbe MR. Association of fluoroquinolone use with short-term risk of development of aortic aneurysm. JAMA Surg 2021. PMID: 33404647 PubMed 
  11. Dong YH, Chang CH, Wang JL, Wu LC, Lin JW, Toh S. Association of Infections and Use of Fluoroquinolones With the Risk of Aortic Aneurysm or Aortic Dissection. JAMA Intern Med. 2020. PMID: 32897358. PubMed 
  12. Gopalakrishnan C, Bykov K, Fischer MA, Connolly JG, Gagne JJ, Fralick M. Association of Fluoroquinolones With the Risk of Aortic Aneurysm or Aortic Dissection. JAMA Intern Med. 2020. PMID: 32897307 PubMed 
  13. Upchurch GR, Schaub TA. Abdominal aortic aneurysm. Am Fam Physician 2006; 73: 1198-204. PubMed 
  14. Fink HA, Lederle FA, Roth CS, Bowles CA, Nelson DB and Haas MA. The accuracy of physical examination to detect abdominal aortic aneurysm. Arch Intern Med 2000; 160: 833-6. PubMed 
  15. Blois B. Office-based ultrasound screening for abdominal aortic aneurysm. Can Fam Physician. 2012;58(3):e172–e178.
  16. Sprouse LR, Meier GH, Parent FN, et al. Is three-dimensional computed tomography reconstruction justified before endovascular aortic aneurysm repair? J Vasc Surg 2004; 40: 443-7. PubMed 
  17. Anderson JL, Halperin JL, Albert NM, et al. Management of patients with peripheral artery disease (compilation of 2005 and 2011 ACCF/AHA guideline recommendations): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;127:1425-1443. PMID: 23457117 PubMed 
  18. Filardo G, Powell JT, Martinez MA-M, Ballard DJ. Surgery for small asymptomatic abdominal aortic aneurysms. Cochrane Database Syst Rev 2012, 14 Mar. CD001835. Cochrane (DOI) 
  19. United Kingdom Small Aneurysm Trial Participants. Long-term outcomes of immediate repair compared with surveillance of small abdominal aortic aneurysms. N Engl J Med 2002; 346: 1445 - 52. PubMed 
  20. Wilson KA, Lee AJ, Lee AJ, Hoskins PR, Fowkes FG, Ruckley CV et al. The relationship between aortic wall distensibility and rupture of infrarenal abdominal aortic aneurysm. J Vasc Surg 2003; 37: 112 - 7. PubMed 
  21. Brown PM, Zelt DT, Sobolev B. The risk of rupture in untreated aneurysms: the impact of size, gender, and expansion rate. J Vasc Surg 2003; 37: 280 - 4. PubMed 
  22. The UK Small Aneurysm Trial Participants. Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms. Lancet 1998; 352: 1649-55 PubMed 
  23. Wesche J. Epidemiologi, utredning og behandlingsindikasjon ved aortaaneurisme. Tidsskr Nor Legeforen 2009; 129: 2124-6. Tidsskrift for Den norske legeforening 
  24. Lederle FA (ed). Abdominal aortic aneurysm - open versus endovascular repair. N Engl J Med 2004; 351: 1677-9. New England Journal of Medicine 
  25. Vetrhus M, Viddal B, Loose H, Neverdal NO, Nordang E. Abdominale aortaaneurismer - endovaskulær og åpen kirurgi. Tidsskr Nor Legeforen 2009; 129: 2248-51. Tidsskrift for Den norske legeforening 
  26. Brady AR, Thompson SG, Fowkes FG, Greenhalgh RM and Powell JT. Abdominal aortic aneurysm expansion: risk factors and time intervals for surveillance. Circulation 2004; 110: 16-21. Circulation 
  27. Norsk legemiddelhåndbok. T8.11.2 Aneurismer. Publisert 12.02.2016. Siden besøkt 28.01.2021. www.legemiddelhandboka.no 
  28. Golledge J, Singh TP Effect of blood pressure lowering drugs and antibiotics on abdominal aortic aneurysm growth: a systematic review and meta-analysis. Heart. 2020. PMID: 33199361 PubMed 
  29. Baxter BT, Matsumura J, Curci JA, et al. Effect of Doxycycline on Aneurysm Growth Among Patients With Small Infrarenal Abdominal Aortic Aneurysms: A Randomized Clinical Trial. JAMA 2020; 323: 2029. pmid:PMID: 32453369 PubMed 
  30. Rughani G, Robertson L, Clarke M. Medical treatment for small abdominal aortic aneurysms. Cochrane Database Syst Rev 2012 Sep 12; 9: CD009536. Cochrane (DOI) 
  31. Coggia M, JaverliatI, Centa Di et al. Total laparoscopic infrarenal aortic aneurysm repair: preliminary results. J Vasc Surg 2004; 40: 448-54. PubMed 
  32. Laxdal E, Amundsen SR, Pedersen G, et al. Bruk av stentgraft ved abdominale aortaaneurismer. Tidsskr Nor Lægeforen 2004; 124: 1237-9. PubMed 
  33. Lundbom J, Hatlinghus S, Lange C, et al. Ni års erfaring med endovaskulær behandling av abdominale aortaaneurismer. Tidsskr Nor Lægeforen 2004; 124: 2757-9. PubMed 
  34. Lederle FA, Freischlag JA, Kyriakides TC, et al. Outcomes following endovascular vs open repair of abdominal aortic aneurysm. JAMA 2009; 302: 1535-42. Journal of the American Medical Association 
  35. De Bruin JL, Baas AF, Buth J, et al. Long-term outcome of open or endovascular repair of abdominal aortic aneurysm. N Engl J Med 2010; 362: 1881-9. New England Journal of Medicine 
  36. The United Kingdom EVAR Trial Investigators. Endovascular versus open repair of abdominal aortic aneurysm. N Engl J Med 2010; 362: 1863-71. PubMed 
  37. EVAR trial participants. Endovascular aneurysm repair versus open repair in patients with abdominal aortic aneurysm (EVAR trial 1): randomised controlled trial. Lancet 2005; 365: 2179-86. PubMed 
  38. EVAR trial participants. Endovascular aneurysm repair and outcome in patients unfit for open repair of abdominal aortic aneurysm (EVAR trial 2): randomised controlled trial. Lancet 2005; 365: 2187-92. PubMed 
  39. Jackson RS, Chang DC, Freischlag JA. Comparison of long-term survival after open vs endovascular repair of intact abdominal aortic aneurysm among Medicare beneficiaries. JAMA 2012; 307: 1621-8. Journal of the American Medical Association 
  40. Kent KC, Zwolak RM, Egorova NN, et al. Analysis of risk factors for abdominal aortic aneurysm in a cohort of more than 3 million individuals. J Vasc Surg 2010; 52: 539. pmid:20630687 PubMed 
  41. Socialstyrelsen. Bukaortaaneurysm – screening med engångsundersökning med ultraljud www.socialstyrelsen.se 
  42. Cosford PA, Leng GC, Thomas J. Screening for abdominal aortic aneurysm. Cochrane Database of Systematic Reviews 2007, Issue 2. Art. No.: CD002945. DOI: 10.1002/14651858.CD002945.pub2. The Cochrane Library 
  43. Ali MU, Fitzpatrick-Lewis D, Miller J, et al. Screening for abdominal aortic aneurysm in asymptomatic adults. J Vasc Surg 2016 Dec; 64(6): 1855-1868. pmid:27871502 PubMed 
  44. Metcalfe D, Holt PJE, Thompson MM. The management of abdominal aortic aneurysms. BMJ 2011; 342: d1384. BMJ (DOI) 
  45. Thompson SG, Ashton HA, Gao L, et al. Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study. BMJ 2009; 338: b2307. BMJ (DOI) 
  46. Guirguis-Blake JM, Beil TL, Senger CA, Whitlock EP. Ultrasonography screening for abdominal aortic aneurysms: A systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med 2014; 160: 321-9. PMID: 24473919 PubMed 
  47. Guirguis-Blake JM, Beil TL, Senger CA, et al. Primary Care Screening for Abdominal Aortic Aneurysm Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA 2019; 322: 2219-38. doi:10.1001/jama.2019.17021 DOI 
  48. Talvitie M, Stenman M, Roy J, Leander K, Hultgren R. Sex Differences in Rupture Risk and Mortality in Untreated Patients With Intact Abdominal Aortic Aneurysms. J Am Heart Assoc. 2021;10(5):e019592. PMID:33619974.
  49. Myhre HO, Ødegård A, Winnerkvist A, Stenseth R. Torakoabdominale aortaaneurismer - åpen kirurgi og endovaskulær behandling. Tidsskr Nor Legeforen 2009; 129: 2127-30. Tidsskrift for Den norske legeforening 
  50. Thompson MM, Sayers RD. Arterial aneurysms. In: Beard JD, Gaines PA, red. Vascular and endovascular surgery. London: Saunders, 1998: 253-85.
  51. Schlösser FJ, Vaartjes I, van der Heiden GJ, et al. Mortality after elective abdominal aortic aneurysm repair. Ann Surg 2010; 25: 158-64. PubMed 
  52. Schermerhorn ML, O'Malley AJ, Jhaveri A, et al. Endovascular vs. open repair of abdominal aortic aneurysm in the medicare population. N Engl J Med 2008; 358: 464-74. New England Journal of Medicine 
  53. Wilmink TB, Quick CR, Hubbard CS and Day NE. The influence of screening on the incidence of ruptured abdominal aortic aneurysms. J Vasc Surg 1999; 30: 203-8. PubMed 
  54. Pleumeekers HJCM, Hoes AW, van der Does E, Van Urk H, Grobbee DE. Epidemiology of abdominal aortic aneurysms. Eur J Vasc Surg 1994; 8: 119-28. PubMed 
  55. Reite A, Søreide K, Ellingsen CL, et al. Epidemiology of ruptured abdominal aortic aneurysms in a well-defined Norwegian population with trends in incidence, intervention rate, and mortality. J Vasc Surg 2015; 61: 1168-74. pmid:25659456 PubMed 
  56. Grootenboer N, van Sambeek MR, Arends LR, Hendriks JM, Hunink MG, Bosch JL. Systematic review and meta-analysis of sex differences in outcome after intervention for abdominal aortic aneurysm. Br J Surg 2010; 97: 1169-79. PubMed 
  57. Frønsdal KB, Sæterdal I, Harboe I, Klemp M, Fure B. Effect of abdominal aortic aneurysm screening. Rapport fra Kunnskapssenteret nr 6 - 2014. ISBN 978-82-8121-854-3 ISSN 1890-1298 brage.bibsys.no 
  58. Lindholt JS, Heegaard NH, Vammen S, Fasting H, Henneberg EW and Heickendorff L. Smoking, but not lipids, lipoprotein(a) and antibodies against oxidised LDL, is correlated to the expansion of abdominal aortic aneurysms. Eur J Vasc Endovasc Surg 2001; 21: 51-6. PubMed 
  59. Vardulaki KA, Walker NM, Day NE, Duffy SW, Ashton HA and Scott RA. Quantifying the risks of hypertension, age, sex and smoking in patients with abdominal aortic aneurysm. Br J Surg 2000; 87: 195-200. PubMed 
  60. Dimick JB, Cowan JA, Stanley JC, Henke PK, Pronovost PJ, Upchurch GR. Surgeon speciality and provider volumes are related to outcome of intact abdominal aortic aneurysm repair in the United States. J Vasc Surg 2003; 38: 739 - 44. PubMed 
  61. Holt PJ, Poloniecki JD, Gerrard D, Loftus IM, Thompson MM. Meta-analysis and systematic review of the relationship between volume and outcome in abdominal aortic aneurysm surgery. Br J Surg 2007; 94: 395-403. PubMed 
  62. Dodd BR, Spence RA. Doxycycline inhibition of abdominal aortic aneurysm growth: a systematic review of the literature. Curr Vasc Pharmacol 2011; 9: 471-8. PubMed 
  63. Lederle FA, Wilson SE, Johnson GE, Reinke DB, Littooy FN, Acher C et al. Immediate repair compared with surveillance of small aortic aneurysms. N Engl J Med 2002; 346: 1437-44. PubMed 
  64. The United Kingdom Small Aneurysm Trial participants. Long-term outcomes of immediate repair compared with surveillance of small abdominal aortic aneurysms. N Engl J Med 2002; 346: 1445-52. PubMed 
  65. Jordan WD, Alcocer F, Wirthlin DJ, Westfall AO, Whitley D. Abdominal aortic aneurysms in "high-risk" surgical patients: comparison of open and endovascular repair. Ann Surg 2003;237: 623-9. PubMed 
  66. Prinssen M, Verhoeven EL, Buth J et al. A randomized trial comparing conventional and endovascular repair of abdominal aortic aneurysms. N Engl J Med 2004; 351: 1607-18. New England Journal of Medicine 
  67. Greenhalgh RM, Brown LC, Kwong GP et al. Comparison of endovascular aneurysm repair with open repair in patients with abdominal aortic aneurysm (EVAR trial 1), 30-day operative mortality results: randomised controlled trial. Lancet 2004; 364: 843-8. PubMed 
  68. Lederle FA, Wilson SE, Johnson GR, et al. Immediate repair compared with surveillance of small abdominal aortic aneurysms. N Engl J Med 2002; 346: 1437-44. PubMed 
  69. Norman PE, Jamrozik K, Lawrence-Brown MM, et al. Population based randomised controlled trial on impact of screening on mortality from abdominal aortic aneurysm. BMJ 2004; 329: 1259. British Medical Journal 
  70. Lindholt JS, Juul S, Fasting H, Henneberg EW. Screening for abdominal aortic aneurysms: single centre randomised controlled trial. BMJ 2005; 330: 750. British Medical Journal 
  71. Ehlers L, Overvad K, Sørensen J, Christensen S, Bech M, Kjølby M. Analysis of cost effectiveness of screening Danish men aged 65 for abdominal aortic aneurysm. BMJ 2009; 338: b2243. BMJ (DOI) 
  72. Lindholt JS, Sørensen J, Søgaard R, Henneberg EW. Long-term benefit and cost-effectiveness analysis of screening for abdominal aortic aneurysms from a randomized controlled trial. Br J Surg 2010; 97: 826-34. PubMed 
  73. Søgaard R, Laustsen J, Lindholt JS. Cost effectiveness of abdominal aortic aneurysm screening and rescreening in men in a modern context: evaluation of a hypothetical cohort using a decision analytical model . BMJ 2012; 345: e4276. BMJ (DOI)