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Stevens-Johnson syndrom og toksisk epidermal nekrolyse

Stevens-Johnson syndrom og toksisk epidermal nekrolyse er sjeldne, akutte, livstruende hudsykdommer som viser seg ved utbredt løsning av hudoverflaten. Tilstandene er nesten alltid forårsaket av et legemiddel.

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Den ligger åpent tilgjengelig på NHI.no sammen annen relevant informasjon

https://nhi.no/sykdommer/hud/blemmeutslett/toksisk-epidermal-nekrolyse/ 

Hva er Stevens-Johnson syndrom og toksisk epidermal nekrolyse?

Årsaker

Symptomer

Hudforandringene

Slimhinneforandringer

Etter den akutte fasen

Diagnostikk

Behandling

Prognose

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Referanser

Dette dokumentet er basert på det profesjonelle dokumentet Stevens-Johnson syndrom og toksisk epidermal nekrolyse. Referanselisten for dette dokumentet vises nedenfor.

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  2. High WA. Stevens-Johnson syndrome and toxic epidermal necrolysis: Pathogenesis, clinical manifestations, and diagnosis. UpToDate, last updated Mar 12, 2019. UpToDate 
  3. Cohen V. Toxic epidermal necrolysis. Medscape, last updated Dec 20, 2018. emedicine.medscape.com 
  4. Letko E, Papaliodis DN, Papaliodis GN et al. Stevens-Johnson syndrome and toxic epidermal necrolysis: a review of the literature. Ann Allergy Asthma Immunol 2005; 94: 419-36. PubMed 
  5. Chung WH, Hung SI, Yang JY, et al. Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med 2008; 14: 1343. pmid:19029983 PubMed 
  6. Caproni M, Torchia D, Schincaglia E, et al. Expression of cytokines and chemokine receptors in the cutaneous lesions of erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis. Br J Dermatol 2006; 155: 722. pmid:16965421 PubMed 
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  17. Paradisi A, Abeni D, Bergamo F, et al. Etanercept therapy for toxic epidermal necrolysis. J Am Acad Dermatol 2014; 71:278. PubMed