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Stevens-Johnson syndrom og toksisk epidermal nekrolyse

Sist oppdatert: Sist revidert:
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Definisjon:
Akutt, livstruende hudsykdom som viser seg ved utbredt erytrodermi, løsning av epidermis og mukosa ledsaget av feber og varierende grad av organinvolvering - oftest legemiddelindusert.
Forekomst:
Insidensen, inklusive Stevens-Johnson syndrom, angis å være ca. 4-7 tilfeller per 1 million innbyggere per år.
Symptomer:
Begynner ofte med prodromer i form av feber og influensalignende symptomer, og ubehag i slimhinner og øyne.
Funn:
Etter 1-3 dager kommer et utslett i ansiktet, på halsen og de sentrale deler av kroppen med et rødt og meslingeliknende utslett som raskt brer seg utover ekstremitetene, og som fører til blemmedannelse og flekkvis løsning av huden.
Diagnostikk:
Klinisk diagnose. Hudstansebiopsi kan bekrefte diagnosen.
Behandling:
Seponering av utløsende medikament og generell intensivbehandling.
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  • Terje Johannessen, professor i allmennmedisin, Trondheim