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Kutant T-cellelymfom (Mycosis fungoides)

Sist oppdatert: Sist revidert:
Sist revidert av:


Definisjon:
Kutant T-cellelymfom er en kompleks samling av tilstander med ulike manifestasjoner, kliniske forløp og terapeutiske betraktninger
Forekomst:
Ca. 6-10 nye tilfeller per år i Norge
Symptomer:
Kutane manifestasjoner og kløe
Funn:
Kliniske funn er tørre, lett skjellende, velavgrensede hudforandringer som kan ha utsparinger, oftest lokalisert nederst på trunkus
Diagnostikk:
Baseres på biopsi og histologi
Behandling:
Tidlig i forløpet potente lokale steroider, senere andre modaliteter og overgang til systemisk behandling
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  3. Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 2016;127(20):2375-90. Blood  
  4. Olsen EA, Whittaker S, Kim YH, et al. Clinical end points and response criteria in mycosis fungoides and Sezary syndrome: a consensus statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer. J Clin Oncol 2011;29:2598-2607. PubMed  
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  15. Weberschock T, Strametz R, Lorenz M, et al. Interventions for mycosis fungoides. Cochrane Database Syst Rev 2012;(9):CD008946. Cochrane (DOI)  
  16. Trautinger F1, Knobler R, Willemze R et al. EORTC consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome. Eur J Cancer 2006; 42: 1014-30. pmid:16574401 PubMed  
  17. Olsen EA, Rook AH, Zic J, et al. Sézary syndrome: immunopathogenesis, literature review of therapeutic options, and recommendations for therapy by the United States Cutaneous Lymphoma Consortium (USCLC). J Am Acad Dermatol. 2011 Feb. 64(2):352-404.
  18. Specht L, Dabaja B, Illidge T, et al. Modern radiation therapy for primary cutaneous lymphomas: field and dose guidelines from the International Lymphoma Radiation Oncology Group. Int J Radiat Oncol Biol Phys 2015; 92:32. PubMed  
  • Terje Johannessen, professor i allmennmedisin, Trondheim

Tidligere fagmedarbeidere

  • Krisitin Ryggen, overlege, hudavdelingen, Regionsykehuset i Trondheim