Anstrengelsesutløst bronkospasme (EIB)
Sist oppdatert: Sist revidert:
Sist revidert av:Peter D. Jost
Definisjon:
Er en forbigående og reversibel luftveisobstruksjon som vanligvis oppstår innen kort tid etter fysisk anstrengelse hos en person med eller uten underliggende astma
Forekomst:
Forekommer først og fremst blant individer som driver med utholdenhetsidretter som krever høy minuttventilasjon. Miljøfaktorer som tørr luft, kulde, allergener og stoffer som irriterer luftveiene kan forverre tilstanden
Symptomer:
Kortpustet, tetthet i brystet, hoste eller hvesing umiddelbart etter eller noen ganger under intens fysisk utholdenhetsaktivitet
Funn:
I akuttfasen foreligger takypné og pipelyder under ekspirasjon. Etter 60 min. hvile normale funn
Diagnostikk:
Tilleggsundersøkelser er spirometri utført i hvile og etter belastning
Behandling:
Oppmuntre til regelmessig fysisk aktivitet. Hurtigvirkende bronkodilaterende medisin (kortidsvirkende β2-agonist eller ICS-formoterol) og oppvarming før hard aktivitet. Gradvis reduksjon av belastning etter hard aktivitet Obs WADAs dopingregler
- Smoliga JM, Weiss P, Rundell KW. Exercise induced bronchoconstriction in adults: evidence based diagnosis and management. BMJ 2016; 352: h6951. pmid:26762594
- Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2022. Available from www.ginasthma.org
- Smoliga JM, Mohseni ZS, Berwager JD, et al. Common causes of dyspnoea in athletes: a practical approach for diagnosis and management. Breathe (Sheff) 2016 Jun; 12(2): e22-37. pmid:27408644 PubMed
- Weiler JM, Anderson SD, Randolph C, et al; American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. Pathogenesis, prevalence, diagnosis, and management of exercise-induced bronchoconstriction: a practice parameter. Ann Allergy Asthma Immunol 2010;105(suppl):S1-47
- Smoliga JM, Weiss P, Rundell KW. Exercise induced bronchoconstriction in adults: evidence based diagnosis and management. BMJ 2016; 352: h6951. pmid:26762594 PubMed
- Weiler JM, Brannan JD, Randolph CC, Hallstrand TS, Parsons J, Silvers W, Storms W, Zeiger J, Bernstein DI, Blessing-Moore J, Greenhawt M, Khan D, Lang D, Nicklas RA, Oppenheimer J, Portnoy JM, Schuller DE, Tilles SA, Wallace D. Exercise-induced bronchoconstriction update-2016. J Allergy Clin Immunol. 2016 Nov;138(5):1292-1295.e36. Epub 2016 Sep 21. PMID: 27665489. PubMed
- Weiss P, Rundell KW. Imitators of exercise-induced bronchoconstriction. Allergy Asthma Clin Immunol. 2009; 5(1): 7. pmid:20016690 PubMed
- de Aguiar KB, Anzolin M, Zhang L. Global prevalence of exercise-induced bronchoconstriction in childhood: A meta-analysis. Pediatr Pulmonol 2018; Jan 24: epub ahead of print. pmid:29364581 PubMed
- Molis MA, Molis WE. Exercise-induced bronchospasm. Sports Health 2010 Jul; 2(4): 311-17. doi:10.1177/1941738110373735 DOI
- Wilber RL, Rundell KW, Szmedra L, Jenkinson DM, Im J, Drake SD. Incidence of exercise-induced bronchospasm in Olympic winter sport athletes. Med Sci Sports Exerc 2000; 32: 732-7. PubMed
- Parsons JP, Mastronarde JG. Exercise-induced bronchoconstriction in athletes. Chest 2005; 128: 3966-74. PubMed
- Weiler JM, Hallstrand TS, Parsons JP, et al. Improving screening and diagnosis of exercise-induced bronchoconstriction: a call to action. J Allergy Clin Immunol Pract 2014; 2(3): 275-80. pmid:24811017 PubMed
- Parsons JP, Hallstrand TS, Mastronarde JG, et al. An official American Thoracic Society clinical practice guideline: exercise-induced bronchoconstriction. Am J Resp Crit Care Med 2013. doi:10.1164/rccm.201303-0437ST DOI
- Weiler JM, Bonini S, Coifman R, et al. Ad Hoc Committee of Sports Medicine Committee of American Academy of Allergy, Asthma & Immunology. American Academy of Allergy, Asthma & Immunology Work Group report: exercise-induced asthma. J Allergy Clin Immunol 2007; 119: 1349-58. PubMed
- Carlsen KH, Anderson SD, Bjermer L, et al. Exercise-induced asthma, respiratory and allergic disorders in elite athletes: epidemiology, mechanisms and diagnosis: part I of the report from the Joint Task Force of the European Respiratory Society (ERS) and the European Academy of Allergy and Clinical Immunology (EAACI) in cooperation with GA2LEN. Allergy 2008 Apr; 63(4): 387-403. pmid:18315727 PubMed
- Pasnick SD, Carlos WG 3rd, Arunachalam A, et al. Exercise-induced bronchoconstriction. Ann Am Thorac Soc 2014 Dec; 11(10): 1651-2. pmid:25549031 PubMed
- Røksund OD, Heimdal JH, Clemm H. Exercise inducible laryngeal obstruction: diagnostics and management. Paediatr Respir Rev 2016 ; Jul 18: S1526-0542. doi:10.1016/j.prrv.2016.07.003 DOI
- Nielsen EW, Hull JH, Backer V. High prevalence of exercise-induced laryngeal obstruction in athletes. Med Sci Sports Exerc 2013 Nov; 45(11): 2030-5. pmid:23657163 PubMed
- Krafczyk MA, Asplund CA. Exercise-induced bronchoconstriction: diagnosis and management. Am Fam Physician 2011: 84; 427-34.
- Langhammer A, Jakobsen A, Sjaastad G, Østrem A. Astmaveileder for allmennpraksis. 2022. www.lungeripraksis.no
- Sonna LA, Angel KC, Sharp MA, Knapik JJ, Patton JF, Lilly CM. The prevalence of exercise-induced bronchospasm among US Army recruits and its effects on physical performance. Chest 2001;119:1676-84. PubMed
- Latorre-Román PÁ, Navarro-Martínez AV, García-Pinillos F. The effectiveness of an indoor intermittent training program for improving lung function, physical capacity, body composition and quality of life in children with asthma. J Asthma 2014 Jun; 51(5): 544-51. pmid:24471516 PubMed
- Carlsen K-H. Fysisk aktivitet og luftveissykdommer, astma og allergi. Tidsskr Nor Lægeforen 2000; 120: 3305-9. Tidsskrift for Den norske legeforening
- Stickland MK, Rowe BH, Spooner CH, et. al. Effect of warm-up exercise on exercise-induced bronchoconstriction. Med Sci Sports Exerc 2012 Mar; 44(3): 383-91. pmid:21811185 PubMed
- Beuther DA, Martin RJ. Efficacy of a heat exchanger mask in cold exercise-induced asthma. Chest 2006; 129: 1188-93. PubMed
- World anti-doping agency. Prohibited list. Publication date 01 Jan 2022. www.wada-ama.org
- Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2022. Available from www.ginasthma.org ginasthma.org
- Koh M, Tee A, Lasserson T, Irving L. Inhaled corticosteroids compared to placebo for prevention of exercise induced bronchoconstriction. Cochrane Database Syst Rev, issue 3, 2007. The Cochrane Library
- Philip G, Pearlman DS, Villarán C, et al. Single-dose montelukast or salmeterol as protection against exercise-induced bronchoconstriction. Chest 2007; 132: 875-83. PubMed
- Leff JA, Busse WW, Pearlman D, Bronsky EA, Kemp J, Hendeles L, et al. Montelukast, a leukotriene-receptor antagonist, for the treatment of mild asthma and exercise-induced bronchoconstriction. N Engl J Med 1998;339:147-52. New England Journal of Medicine
- Raissy HH, Harkins M, Kelly F, Kelly HW. Pretreatment with albuterol versus montelukast for exercise-induced bronchospasm in children. Pharmacotherapy 2008; 28: 287-94. PubMed
- Edelman JM, Turpin JA, Bronsky EA, et al. Oral montelukast compared with inhaled salmeterol to prevent exercise-induced bronchoconstriction. A randomized, double-blind trial. Exercise Study Group. Ann Intern Med 2000; 132: 97-104. Annals of Internal Medicine
- FDA. Press Announcements. FDA Requires Stronger Warning About Risk of Neuropsychiatric Events Associated with Asthma and Allergy Medication Singulair and Generic Montelukast. March 2020. www.fda.gov
- Tan RA, Spector SL. Exercise-induced asthma: diagnosis and management. Ann Allergy Asthma Immunol 2002;89:226-35. PubMed
- Wilkinson M, Hart A, Milan SJ, et al. Vitamins C and E for asthma and exercise-induced bronchoconstriction. Cochrane Database Syst Rev. 2014 Jun; 17;(6): CD010749. doi:10.1002/14651858.CD010749.pub2. DOI
- World Anti-Doping Agency. Prohibited at all times. Beta-2 agonists. www.wada-ama.org
- Antidoping Norge. Regler. Dopinglisten. Dopinggruppe S3: beta-2 agonister antidoping.no
- Tan RA, Spector SL. Exercise-induced asthma. Sports Med 1998;25:1-6. PubMed
- O'Byrne PM, Barnes PJ, Wood RA. Exercise-induced bronchoconstriction. www.uptodate.com , sist oppdatert 23.10.2019. Siden besøkt 6.8.2020. UpToDate
- Grove A, Lipworth BJ. Bronchodilator subsensitivity to salbutamol after twice daily salmeterol in asthmatic patients. Lancet 1995;346:201-6. PubMed
- Antidoping Norge. Legemiddelsøk. Symbicort. Siden besøkt 21.05.2021. www.antidoping.no
- Peter D. Jost, spesialist i allmennmedisin, redaktør NEL, Trondheim
- Arnulf Langhammer MD, Phd., Professor. NTNU, HUNT forskningssenter, Levanger