Hopp til hovedinnhold

Cøliaki, symptomer

Typiske symptomer ved cøliaki er løse og hyppige avføringer, magesmerter, vekttap og slapphet. Mange er syke i flere år før de får diagnosen.

Sist revidert:

QR
Del pasientinformasjon

Den ligger åpent tilgjengelig på NHI.no sammen annen relevant informasjon

https://nhi.no/sykdommer/barn/magetarm/coliaki-symptomer/ 

Hvilke plager kan cøliaki gi?

Hypersensitivitet til gluten?

Hvilke andre tilstander kan ligne på cøliaki?

Vil du vite mer?

Quiz

Kilder

Referanser

Dette dokumentet er basert på det profesjonelle dokumentet Cøliaki. Referanselisten for dette dokumentet vises nedenfor.

  1. Størdal K, Kahrs C, Holm HK. Cøliaki hos barn. Generell veileder i pediatri, 2020. www.helsebiblioteket.no 
  2. Ludvigsson JF, Leffler DA, Bai JC, et al. The Oslo definitions for coeliac disease and related terms. Gut. 2013;62:43–52.
  3. Rubin JE, Crowe SE. Celiac disease. Ann Intern Med. 2020;172(1):ITC1-ITC16. PMID: 31905394 PubMed 
  4. Lebwohl B, Ludvigsson JF, Green PH. Celiac disease and non-celiac gluten sensitivity. BMJ 2015; 351: h4347. PMID: 26438584. PubMed 
  5. Lebwohl B, Sanders DS, Green PHR. Coeliac disease. Lancet 2018; 392 (10115): 70-81. PMID: 28760445. PubMed 
  6. Deressa E, Wammer AC, Falch JA, Jahnsen J. Beinmetabolisme hos nydiagnostiserte cøliakipasienter. Tidsskr Nor Lægeforen 2006; 126: 1201-4. PubMed 
  7. Kelly CP, Bai JC, Liu E, Leffler DA. Advances in diagnosis and management of celiac disease. Gastroenterology. 2015 May; 148(6): 1175–1186. . doi:10.1053/j.gastro.2015.01.044 DOI 
  8. Ludvigsson JF, Rubio-Tapia A, van Dyke CT, et al. Increasing incidence of celiac disease in a North American population. Am J Gastroenterol. 2013;108:818–24.
  9. Størdal K, Bakken IJ, Surén P et al. Epidemiology of coeliac disease and comorbidity in Norwegian children. J Pediatr Gastroenterol Nutr 2013; 57: 467 – 71. PMID: 23863325 PubMed 
  10. Catassi C, Kryszak D, Louis-Jacques O, et al. Detection of celiac disease in primary care: a multicenter case-finding study in North America. Am J Gastroenterol 2007; 102: 1454-60. PubMed 
  11. Silano M, Agostoni C, Sanz Y, et al. Infant feeding and risk of developing celiac disease: a systematic review. BMJ Open. 2016 Jan 25;6(1):e009163. pmid: 26810996. PubMed 
  12. Green PH. The many faces of celiac disease: clinical presentation of celiac disease in the adult population. Gastroenterology 2005;128:S74-S78.
  13. Singh P, Arora S, Lal S, et al. Risk of celiac disease in the first- and second-degree relatives of patients with celiac disease: a systematic review and meta-analysis. Am J Gastroenterol, 29 September 2015 . doi:10.1038/ajg.2015.296 DOI 
  14. Liu E, et al. Risk of pediatric celiac disease according to HLA haplotype and country. N EnglJ Med 2014; 371: 42. doi:10.1056/NEJMoa1313977 DOI 
  15. Kahrs CR, Chuda K, Tapia G, et al. Enterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohort. BMJ 2019; 364: I231. pmid:30760441 PubMed 
  16. Szajewska H, Shamir R, Mearin L et al. Gluten Introduction and the Risk of Coeliac Disease: A Position Paper by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2016; 62: 507-13. pmid:26815017 PubMed 
  17. Al-Toma A, Volta U, Auricchio R, et al. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastroenterology Journal. 2019;7(5):583-613. PMID: 31210940. PubMed 
  18. Lund-Blix NA, Mårild K, Tapia G et al. Gluten Intake in Early Childhood and Risk of Celiac Disease in Childhood: A Nationwide Cohort Study. Am J Gastroenterol 2019; 114: 1299-1306. pmid:31343439 PubMed 
  19. Andrén Aronsson C, Lee HS, Hård Af Segerstad EM et al. Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk. JAMA 2019; 322: 514-23. pmid:31408136 PubMed 
  20. Wijarnpreecha K, Lou S, Panjawatanan P et al. Cigarette smoking and risk of celiac disease: A systematic review and meta-analysis. United European Gastroenterol J 2018; 6: 1285-93. pmid:30386601 PubMed 
  21. Husby S, Koletzko S, Korponay-Szabó IR, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J Pediatr Gastroenterol Nutr 2019 Oct 17. www.espghan.org 
  22. Penny HA, Raju SA, Lau MS, et al. Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts. Gut 2021; 70: 876. PMID: 33139268 PubMed 
  23. Cristofori F, Fontana C, Magista A, et al. Increased prevalence of celiac disease among pediatric patients with irritable bowel syndrome. A 6-year prospective chort study. JAMA Pediatr 2014. doi:10.1001/jamapediatrics.2013.4984 DOI 
  24. Carroccio A, Mansueto P, Iacono G, et al. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: Exploring a new clinical entity. Am J Gastroenterol, 24 July 2012. doi:10.1038/ajg.2012.236 DOI 
  25. Therrien A, Kelly CP. Coeliac disease. BMJ Best Practice, last updated 20 Oct 2020. bestpractice.bmj.com 
  26. Goel G, Tye-Din JA, Qiao S-W, et al. Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease. Science Advances 07 Aug 2019 . advances.sciencemag.org 
  27. Pastore L, Carroccio A, Compilato D, et al. Oral manifestations of celiac disease. J Clin Gastroenterol. 2008;42:224-232. PubMed 
  28. Hadjivassiliou M, Sanders DS, Grünewald RA, et al. Gluten sensitivity: from gut to brain. Lancet Neurol 2010; 9: 318-30. PubMed 
  29. Nemec G, et al. Looking for celiac disease: diagnostic accuracy of two rapid commercial assays. Am J Gastroenterol 2006; 101: 1597-600. PubMed 
  30. Rokkas T, Niv Y. The role of video capsule endoscopy in the diagnosis of celiac disease: a meta-analysis. Eur J Gastroenterol Hepatol. 2012;24:303–8.
  31. Garsed K, Scott BB. Can oats be taken in a gluten-free diet? A systematic review. Scand J Gastroenterol 2007; 42: 171-8. PubMed 
  32. Løvik A, Lundin KEA. Kostbehandling av cøliaki og dermatitis herpetiformis. Tidsskr Nor Lægeforen 2003; 123: 3237 - 40. PubMed 
  33. Catassi C, Fabiani E, Iacono G, et al. A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. Am J Clin Nutr. 2007;85:160–6.
  34. Schuppan D, Mäki M, Lundin KEA, et al. A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease. N Engl J Med. 2021;385(1):35-45. doi:10.1056/NEJMoa2032441 DOI 
  35. Jabri B. Transglutaminase 2 Inhibition for Prevention of Mucosal Damage in Celiac Disease. N Engl J Med. 2021 Jul 1;385(1):76-77. doi: 10.1056/NEJMe2107502.
  36. Johnson D. Novel Drug for Celiac Disease Reduces GI and Non-GI Symptoms. Digestive Disease Week (DDW) 2014. Abstract 929f. Presented May 7, 2014.
  37. Castillo NE, Theethira TG, Leffler DA. The present and the future in the diagnosis and management of celiac disease. Gastroenterol. Rep. (2015) 3 (1): 3-11.
  38. Lionetti E, Castellaneta S, Francavilla R, et al. Introduction of gluten, HLA status, and the risk of celiac disease in children. N Engl J Med 2014;371:1295-1303. New England Journal of Medicine 
  39. Vriezinga SL, Auricchio R, Bravi E, et al. Randomized feeding intervention in infants at high risk for celiac disease. N Engl J Med 2014;371:1304-1315 New England Journal of Medicine 
  40. Sultan AA, Crooks CJ, Card T, et al. Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis. Gut. Published Online First 24 October 2014 . doi:10.1136/gutjnl-2014-308285 DOI 
  41. Ilus T, Kaukinen K, Virta LJ, et al. Incidence of malignancies in diagnosed celiac patients. Am J Gastroenterol 2014; 109(9): 1471-77. PubMed 
  42. Lebwohl B, Granath F, Ekbom A, et al. Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: a population-based cohort study. Ann Intern Med 2013;159(3):169-175. doi:10.7326/0003-4819-159-3-201308060-00006 DOI 
  43. Mirza F, Canalis E. Management of endocrine disease: Secondary osteoporosis: pathophysiology and management. Eur J Endocrinol. 2015;173(3):R131-R151. PMID: 25971649 PubMed 
  44. Dhalwani NN, West J, Sultan AA, et al. Women with celiac disease present with fertility problems no more often than women in the general population. Gastroenterology. 2014 Dec;147(6):1267-74. PubMed 
  45. Wierdsma NJ, van Bokhorst-de van der Schueren MA, Berkenpas M, et al. Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. Nutrients. 2013;5:3975–92.
  46. Thawani SP, Brannagan TH, Lebwohl B, et al. Risk of neuropathy among 28 232 patients with biopsy-verified Celiac disease . JAMA Neurology 2015. doi:10.1001/jamaneurol.2015.0475 DOI 
  47. Evans KE, Leeds JS, Morley S et.al. Pancreatic insufficiency in adult celiac disease: do patients require long-term enzyme supplementation?. Dig Dis Sci 2010; 55: 2999-3004. PubMed 
  48. Quarpong W, Card TR, West J, Solaymani-Dodaran M, Logan RF, Grainge MJ. Mortality in people with coeliac disease: Long-term follow-up from a Scottish cohort. United European Gastroenterol J. 2019;7(3):377-387. PMID: 31019706. PubMed 
  49. Lebwohl B, Green PHR, Söderling J, Roelstraete B, Ludvigsson JF. Association Between Celiac Disease and Mortality Risk in a Swedish Population. JAMA. 2020;323(13):1277-1285. PubMed 
  50. Pekki H, Kurppa K, Mäki M, et al. Predictors and significance of incomplete mucosal recovery in celiac disease after 1 year on a gluten-free diet. Am J Gastroenterol. 2015;110(7):1078-1085. PubMed 
  51. Sultan AA, Tata LJ, Fleming KM, et al. Pregnancy complications and adverse birth outcomes among women with celiac disease. Am J Gastroenterol. 2014;109:1653-1661. PubMed 
  52. Fagrådet i Norsk Cøliakiforening. Retningslinjer - cøliaki, 2017. www.ncf.no