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Primær biliær kolangitt

Sist revidert:
Sist revidert av:


Definisjon:
En autoimmun, kronisk, kolestatisk sykdom i de intrahepatiske galleganger med inflammasjon, fibrose og til slutt leversvikt. Sykdommen ble tidligere kalt primær biliær cirrhose
Forekomst:
Sjelden. Prevalens 150-400 per million
Symptomer:
Tidlige tegn er slapphet, plagsom kløe og uforklarlig hyperlipidemi
Funn:
Hepatosplenomegali, hyperpigmentering, xantomatøse lesjoner kan forekomme i hud, sener eller rundt øyebryn. Ikterus eventuelt, men er et sent innsettende tegn
Diagnostikk:
Biokjemiske prøver viser kolestatisk mønster. Anti-mitokondrie-antistoffer har høy sensitivitet og spesifisitet
Behandling:
Primært symptomatisk. Ursodeoksykolsyre brukes mye, men har usikker effekt
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  • Terje Johannessen, professor i allmennmedisin, Trondheim (tilpasning til NEL)

Tidligere fagmedarbeidere

  • Eiliv Brenna, overlege, Medisinsk avdeling, Regionsykehuset i Trondheim
  • Svein Ødegaard, overlege og professor, Haukeland sykehus og Nasjonalt senter for gastroenterologisk ultrasonografi, Bergen