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Hepatocellulært karsinom

Sist oppdatert: Sist revidert:
Sist revidert av:


Definisjon:
Er en primær leverkreftsykdom som utgår fra hepatocytter, vanligvis i forløpet av en kronisk leversykdom, særlig virushepatitt
Forekomst:
Lav forekomst i Norge fordi insidensen av hepatitt er lav
Symptomer:
Pasientene har som regel symptomer fra den underliggende kroniske leversykdommen og man blir oppmerksom på tilstanden ved rask forverring
Funn:
Tegn på den tilgrunnliggende sykdommen, cirrhose/leversvikt, forekommer i form av spenomegali, ascites, ikterus, spider nevi, gynekomasti
Diagnostikk:
Tilleggsundersøkelser viser forhøyet ALAT, ALP, GT, bilirubin og lav NT, albumin, trombocytter, ev. alfaføtoprotein. Bildediagnostikk + biopsi
Behandling:
Kirurgisk fjerning av svulster, leverreseksjon, er vanligvis nytteløst dersom cirrhose er tilstede og svulsten er stor eller multifokal. Ev. levertransplantasjon
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  12. Yu NC, Chaudhari V, Raman SS, et al. CT and MRI improve detection of hepatocellular carcinoma, compared with ultrasound alone, in patients with cirrhosis. Clin Gastroenterol Hepatol 2011; 9:161. PubMed  
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  16. Taefi A, Abrishami A, Nasseri-Moghaddam S, Eghtesad B, Sherman M. Surgical resection versus liver transplant for patients with hepatocellular carcinoma. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD006935. DOI: 10.1002/14651858.CD006935.pub2. DOI  
  17. Awad T, Thorlund K, Gluud C. Cryotherapy for hepatocellular carcinoma. Cochrane Database of Systematic Reviews 2009, Issue 4. Art. No.: CD007611. DOI: 10.1002/14651858.CD007611.pub2. DOI  
  18. Zhong JH, Li LQ, Wu LC. Lamivudine with or without adefovir dipivoxil for postoperative hepatocellular carcinoma. Cochrane Database of Systematic Reviews 2011, Issue 12. Art. No.: CD008713. DOI: 10.1002/14651858.CD008713.pub2. DOI  
  19. Oliveri RS, Wetterslev J, Gluud C. Transarterial (chemo)embolisation for unresectable hepatocellular carcinoma. Cochrane Database of Systematic Reviews 2011, Issue 3. Art. No.: CD004787. DOI: 10.1002/14651858.CD004787.pub2. DOI  
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  • Terje Johannessen, professor i allmennmedisin, Trondheim

Tidligere fagmedarbeidere

  • Lars Aabakken, førsteamanuensis ved Universitetet i Oslo, lege ved Medisinsk avdeling, Rikshospitalet