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Eosinofil øsofagitt

Sist revidert:
Sist revidert av:

Definisjon:
Eosinofil øsofagitt er en inflammatorisk tilstand i spiserøret karakterisert ved eosinofil infiltrasjon, forårsaket av antigener i matvarer
Forekomst:
Tilstanden rammer typisk barn og unge voksne
Symptomer:
Tilstanden er karakterisert ved intermitterende dysfagi og episoder med fastsittende mat i øsofagus
Funn:
Ingen spesifikke kliniske funn
Diagnostikk:
Diagnosen stadfestes ved endoskopi og histologi med biopsier fra nedre og midtre øsofagus med påvisning av eosinefile infiltrater
Behandling:
Aktuelle tiltak er å identifisere og eliminere underliggende allergener, lokal medikamentell behandling og ev. endoskopisk behandling av strikturer
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  3. Carlson M, Dlugosz A. Utredning och behandling av esosinofil esofagit. Svensk Gastroenterologisk Förening, 2020.
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  9. Wolf WA, Jerath MR, Sperry SL, et al. Dietary elimination therapy is an effective option for adults with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2014;12:1272-79 . PubMed  
  10. Dharmaraj R, Hagglund K, Lyons H. Eosinophilic esophagitis associated with celiac disease in children. BMC Research Notes 2015; 8: 263. doi:10.1186/s13104-015-1256-z DOI  
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  12. Dellon ES, Liacouras CA. Advances in clinical management of eosinophilic esophagitis. Gastroenterology 2014; 147: 1238-54. pmid:25109885 PubMed  
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  14. Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 2007; 133: 1342-63. Gastroenterology  
  15. Lucendo AJ, Miehlke S, Schlag C, et al. Efficacy of Budesonide Orodispersible Tablets as Induction Therapy for Eosinophilic Esophagitis in a Randomized Placebo-Controlled Trial. Gastroenterology. 2019;157(1):74-86.e15. PMID: 30922997. PubMed  
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  17. Vazquez-Elizondo G, Ngamruengphong S, Khrisna M, et al. The outcome of patients with oesophageal eosinophilic infiltration after an eight-week trial of a proton pump inhibitor. Aliment Pharmacol Ther 2013; 38:1312. PubMed  
  • Terje Johannessen, professor i allmennmedisin, Trondheim
  • Ingard Løge, spesialist allmennmedisin, redaktør NEL