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Clostridioides difficile tarminfeksjon

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Definisjon:
Tarminfeksjon forårsaket av bakterien Clostridioides difficile sekundært til antibiotikabehandling
Forekomst:
Forekomst er tiltakende på grunn av økende bruk av bredspektrede antibiotika, og en av de hyppigste årsakene til nosokomial diaré
Symptomer:
Symptomene kommer oftest 2-4 uker etter påbegynt antibiotikabehandling og består i hyppig og løs avføring, av og til med blod eller slim
Funn:
Kliniske funn er svekket allmenntilstand, ev. dehydrering
Diagnostikk:
Tilleggsundersøkelser er målinger av infeksjonsparametre, PCR i avføringsprøve, us. på toksiner, ev. dyrkning
Behandling:
Behandlingen avhenger av alvorlighetsgraden. Lettere tilfeller behøver ikke behandling, alvorligere tilfeller behandles med metronidazol eller vancomycin. Fæcestransplantasjon aktuelt ved residiverende sykdom
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  • Terje Johannessen, professor i allmennmedisin, Trondheim
  • Ingard Løge, spesialist allmennmedisin, redaktør NEL

Tidligere fagmedarbeidere

  • Hermod Petersen, professor i gastroenterologi, Norges teknisk-naturvitenskapelige universitet og overlege i gastroenterologi, Regionsykehuset i Trondheim
  • Dag Berild, overlege, Medisinsk klinikk, Aker Sykehus
  • Bjørg Viggen, overlege, Gastroenterologisk seksjon, Medisinsk avdeling, Regionsykehuset i Trondheim