Whipples sykdom
Sist revidert:
Sist revidert av:Terje Johannessen
Definisjon:
Er en infeksjonssykdom forårsaket av bakterien Tropheryma whipplei
Forekomst:
Tilstanden er meget sjelden
Symptomer:
Sykdommen er karakterisert ved langvarig forløp med vekttap, diaré, magesmerter og leddsmerter. Sentralnervesystemet er også affisert hos ca. 50%
Funn:
Kliniske funn kan vise tegn til malabsorpsjon, leddbetennelser, ev. nevrologiske utfall
Diagnostikk:
Tilstanden kan påvises ved å måle serum antistoffrespons, immunpåvisning av antigen i vevsbiopsi og utvikling av cellefrie kulturmedia
Behandling:
Antibiotika
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- Fenollar F, Fournier PE, Robert C, Raoult D. Use of genome selected repeated sequences increases the sensitivity of PCR detection of Tropheryma whipplei. J Clin Microbiol 2004; 42: 401-3. PubMed
- Schnider PJ, Reisinger EC, Gerschlager W, et al. Long-term follow-up in cerebral Whipple's disease. Eur J Gastroenterol Hepatol 1996; 8: 899-903. PubMed
- Terje Johannessen, professor i allmennmedisin, Trondheim
Tidligere fagmedarbeidere
- Dag Berild, overlege, Medisinsk klinikk, Aker Sykehus