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Whipples sykdom

Sist revidert:
Sist revidert av:


Definisjon:
Er en infeksjonssykdom forårsaket av bakterien Tropheryma whipplei
Forekomst:
Tilstanden er meget sjelden
Symptomer:
Sykdommen er karakterisert ved langvarig forløp med vekttap, diaré, magesmerter og leddsmerter. Sentralnervesystemet er også affisert hos ca. 50%
Funn:
Kliniske funn kan vise tegn til malabsorpsjon, leddbetennelser, ev. nevrologiske utfall
Diagnostikk:
Tilstanden kan påvises ved å måle serum antistoffrespons, immunpåvisning av antigen i vevsbiopsi og utvikling av cellefrie kulturmedia
Behandling:
Antibiotika
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  3. Whipple GH. A hitherto undescribed disease characterised anatomically by deposits of fat and fatty acids in the intestinal mesenteric lymphatic tissue. Johns Hopkins Hospital Bulletin 1907; 18: 382-91. PubMed  
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  16. Fenollar F, Raoult D. Molecular techniques in Whipple's disease. Expert Rev Mol Diagn 2001; 1: 299-309. PubMed  
  17. Fenollar F, Fournier PE, Robert C, Raoult D. Use of genome selected repeated sequences increases the sensitivity of PCR detection of Tropheryma whipplei. J Clin Microbiol 2004; 42: 401-3. PubMed  
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  • Terje Johannessen, professor i allmennmedisin, Trondheim

Tidligere fagmedarbeidere

  • Dag Berild, overlege, Medisinsk klinikk, Aker Sykehus