Hopp til hovedinnhold

Autonome perifere nevropatier

Sist revidert:
Sist revidert av:
Definisjon:
Autonome nervefibre skades ved de fleste symmetriske perifere nevropatier som skyldes systemsykdommer
Forekomst:
Er ganske utbredt
Symptomer:
Slike skader forårsaker en mengde forskjellige symptomer og tegn som inkluderer kardiovaskulære, gastrointestinale, urogenitale, termoregulerende, sudomotor og pupillomotor autonome funksjoner
Funn:
Avhenger av underliggende tilstand
Diagnostikk:
Andre undersøkelser avhenger av underliggende tilstand
Behandling:
Mange autonome nevropatiene er irreversible, men symptomene på autonom dysfunksjon kan respondere på flere spesifikke intervensjoner
  1. Freeman R. Autonomic peripheral neuropathy. Lancet 2005; 365: 1259-70. PubMed  
  2. Tesfaye S, Boulton AJ, Dyck PJ, et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care 2010; 33:2285. PubMed  
  3. Vinik AI, Erbas T. Diabetic autonomic neuropathy. Handb Clin Neurol 2013; 117:279. PubMed  
  4. Freeman R. Diabetic autonomic neuropathy. Handb Clin Neurol 2014; 126:63. PubMed  
  5. Fleg JL, Evans GW, Margolis KL, et al. Orthostatic Hypotension in the ACCORD (Action to Control Cardiovascular Risk in Diabetes) Blood Pressure Trial: Prevalence, Incidence, and Prognostic Significance. Hypertension 2016; 68:888. PubMed  
  6. Kempler P, Amarenco G, Freeman R, et al. Management strategies for gastrointestinal, erectile, bladder, and sudomotor dysfunction in patients with diabetes. Diabetes Metab Res Rev 2011; 27:665. PubMed  
  7. Gibbons CH. Diabetic autonomic neuropathy. UpToDate, last updated Feb 08, 2021. UpToDate  
  8. Pasricha PJ, Grover M, Yates KP, et al. Functional dyspepsia and gastroparesis in tertiary care are interchangeable syndromes with common clinical and pathologic features. Gastroenterology 2021; 160: 2006-17. PMID: 33548234 PubMed  
  9. Gibbons CH. Diabetic autonomic neuropathy. UpToDate, last updated Mar 12, 2019. UpToDate  
  10. Gorevic PD. Overview of amyloidosis. UpToDate, last updated Feb 07, 2019. UpToDate  
  11. Yuki N, Hartung HP. Guillain-Barré syndrome. N Engl J Med 2012; 366:2294. New England Journal of Medicine  
  12. Mukerji S, Aloka F, Farooq MU, et al. Cardiovascular complications of the Guillain-Barré syndrome. Am J Cardiol 2009; 104:1452. PubMed  
  13. Adler BL, Russell JW, Hummers LK, McMahan ZH. Symptoms of Autonomic Dysfunction in Systemic Sclerosis Assessed by the COMPASS-31 Questionnaire. J Rheumatol. 2018;45(8):1145-1152. PubMed  
  14. Dalmau J, Rosenfeld MR. Paraneoplastic syndromes affecting peripheral nerve and muscle. UpToDate, last updated Dec 12, 2017. UpToDate  
  15. Kesner VG, Oh SJ, Dimachkie MM, Barohn RJ. Lambert-Eaton Myasthenic Syndrome. Neurol Clin. 2018;36(2):379-394. PubMed  
  16. Schiffmann R. Fabry disease: Neurologic manifestations. UpToDate, last updated Feb 20, 2019. UpToDate  
  17. Pegram PS, Stone SM. Botulism. UpToDate, last updated Apr 08, 2019. UpToDate  
  18. Ferrari S, Vento S, Monaco S, et al. Human immunodeficiency virus-associated peripheral neuropathies. Mayo Clin Proc 2006; 81:213. PubMed  
  19. Morrison B, Chaudhry V. Medication, toxic, and vitamin-related neuropathies. Continuum (Minneap Minn) 2012; 18:139. PubMed  
  20. Mills PB, Fung CK, Travlos A, Krassioukov A. Nonpharmacologic Management of Orthostatic Hypotension: A Systematic Review. Arch Phys Med Rehabil 2015; 96: 366-75. doi: 10.1016/j.apmr.2014.09.028. DOI  
  • Terje Johannessen, professor i allmennmedisin, Trondheim (tilpasning til NEL)

Tidligere fagmedarbeidere

  • Jakob Christensen, overlæge, Neurologisk afdeling F, Århus
  • Michael Bjørn Russell, prof., overlæge, ph.d., dr. med., Neurologisk afd., Akershus Universitetssygehus, Oslo