Narkolepsi
Sist oppdatert: Sist revidert:
Sist revidert av:Bjørn Bjorvatn
Definisjon:
Kronisk søvnforstyrrelse karakterisert ved uttalt søvnighet på dagtid med søvnanfall, og ofte katapleksi, hypnagoge hallusinasjoner og søvnparalyse. Arvelige faktorer kan være av betydning
Forekomst:
Det er beregnet å være ca. 2000-2500 pasienter her i landet. Er uvanlig hos barn, men symptomene starter ofte i ungdomsalder
Symptomer:
Symptomene er økt søvnighet og anfallsvis svært sterk søvntrang på dagtid. Typisk er også katapleksi, hypnagoge hallusinasjoner og søvnparalyse
Funn:
Den fysiske undersøkelsen er normal
Diagnostikk:
Tester i søvnlaboratorium anbefales for sikker diagnose
Behandling:
Behandlingen består av informasjon og tilrettelegging i arbeid eller skole. Medikamentell behandling er aktuelt mot søvnigheten og mot katapleksi og hypnagoge hallusinasjoner
- Zeman A, Britton T, Douglas N, et al. Narcolepsy and excessive daytime sleepiness. BMJ 2004; 329: 724-8. PubMed
- Guilleminault C, Brooks SN. Excessive daytime sleepiness. Brain 2001; 124: 1482-91. PubMed
- Scammell TE. Narcolepsy. N Engl J Med. 2015; 373:2654-62. pmid:26716917 PubMed
- Britton T, Douglas N, Hansen A, Hicks J, Howard R, Meredith A, et al. Guidelines on the diagnosis and management of narcolepsy in adults and children. Ashtead: Taylor Patten Communications, 2002 (available at www.sleeping.org.uk or www.primarycaresleep.com).
- Overeem S, Mignot E, van Dijk JG, Lammers GJ. Narcolepsy: clinical features, new pathophysiologic insights and future perspectives. J Clin Neurophysiol 2001; 18: 78-105. PubMed
- Billiard M. Diagnosis of narcolepsy and idiopathic hypersomnia: an update based on the international classification of sleep disorders, 2nd edition. Sleep Med Rev 2007; 11: 377–88.
- Silber MH, Krahn LE, Pankratz VS. The epidemiology of narcolepsy in Olmstead County, Minnesota: a population-based study. Sleep 2002; 25: 197-202. PubMed
- Longstreth WT Jr, Koepsell TD, Ton TG. The epidemiology of narcolepsy. Sleep 2007; 30: 13. pmid:17310860 PubMed
- Heier MS, Evsiukova T, Wilson J, et al. Prevalence of narcolepsy with cataplexy in Norway. Acta Neurol Scand 2009; 120: 276-80. PubMed
- Sand T, Schrader H. Narkolepsi og andre hypersomnier. Oversiktsartikkel. Tidsskr Nor Legeforen 2009; 129: 2007-10. Tidsskrift for Den norske legeforening
- NevSom - Nasjonalt kompetansesenter for nevroutviklingsforstyrrelser og hypersomnier. Narkolepsi. Nettsiden publisert 24.01.2018 og sist oppdatert 23.03.2020 legehandboka.no
- Ruge Møller L, Østergaard JR. Narkolepsi hos børn - en overset diagnose. Ugeskr Læger 2005; 167: 2390-3. PubMed
- Mignot E, Lammers GJ, Ripley B, et al. The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol 2002; 59: 1553. doi:12374492
- Dauvilliers Y, Montplaisir J, Molinari N, et al. Age at onset of narcolepsy in two large populations of patients in France and Quebec. Neurology 2001; 57: 2029. pmid:11739821 PubMed
- Allele Frequency Net Database: Søk gjort 23.03.20. www.allelefrequencies.net
- Mignot E. Genetic and familial aspects of narcolepsy. Neurology 1998; 50: Suppl 1 (S16-22). pmid:9484418 PubMed
- National institute for health and welfare. Association between Pandemrix and narcolepsy confirmed among Finnish children and adolescents. Sept. 1, 2011.
- Sarkanen T, Alakuijala A, Partinen M. Clinical course of H1N1-vaccine-related narcolepsy. Sleep Med 2016; 19: 17-22. pmid:27198942 PubMed
- Søvnsykdommen narkolepsi blant barn og unge etter pandemien 2009/2010. Folkehelseinstituttet 2013
- Pace-Schott EF, Hobson JA. The neurobiology of sleep. Nat Rev Neurosci 2002; 3: 591-605. PubMed
- Hobson JA, Pace-Schott EF. The cognitive neuroscience of sleep. Nat Rev Neurosci 2002; 3: 670-93. PubMed
- Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E. Hypocretin (orexin) deficiency in human narcolepsy letter. Lancet 2000; 355: 39-40. PubMed
- Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, et al. A mutation in a case of early onset narcolepsy and a generalised absence of hypocretin peptides in human narcoleptic brains. Nat Med 2000; 6: 991-7. PubMed
- Thannickal TC, Moore RY, Nienhuls R, Ramanathan L, Gulyani S, Aldrich M, et al. Reduced numbers of hypocretin neurons in human narcolepsy. Neuron 2000; 27: 469-74. PubMed
- Scammell T. The neurobiology, diagnosis and treatment of narcolepsy. Ann Neurol 2003; 53: 154-66. PubMed
- Tafti M, Hor H, Dauvilliers Y, et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe. Sleep 2014; 37: 19-25. pmid:24381371 PubMed
- Miyagawa T, Tokunaga K. Genetics of narcolepsy. Hum Genome Var 2019; 8: eCollection 2019. pmid:30652006 PubMed
- Judd BG, Sateia MJ. Classification of sleep disorders. UpToDate 2017 - last updated may 2015. www.uptodate.com
- Guilleminault C, Pelayo R. Nacolepsy in children. Paediatr Drugs 2000; 2-9.
- Merrill S, Wise MD. Childhood narcolepsy. Neurology 1998; 50(suppl 1): S37-S42.
- McKenna L, McNicholas F. Childhood onset narcolepsy. Eur Child Adolesc Psychiatry 2003; 12: 43-7. PubMed
- Babiker MO, Prasad M. Narcolepsy in children: a diagnostic and management approach. Pediatr Neurol 2015; 52: 557-65. pmid:25838042 PubMed
- Daniels E, King MA, Smith IE, Shneerson JM. Health-related quality of life in narcolepsy. J Sleep Res 2001; 10: 75-81. PubMed
- Standard of Practice Committee, American Academy of Sleep Medicine. Practice parameters for the treatment of narcolepsy. Sleep 2001; 24: 451-66. PubMed
- Dauvilliers Y, Lecendreux M, Lammers GJ, et al. Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy: a double-blind, randomised, placebo-controlled trial. Lancet Neurol 2023; 22: 303-311. pmid:36931805 PubMed
- Rogers AE, Aldrich MS, Lin X. A comparison of three different sleep schedules for reducing daytime sleepiness in narcolepsy. Sleep 2001; 24: 385-91. PubMed
- Scammell TE, Benca R. Treatment of narcolepsy. UpToDate 2013 UpToDate
- US Modafinil in Narcolepsy Multicenter Study Group. Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy. Neurology 2000; 54: 1166-75. Neurology
- Vignatelli L, D'Alessandro R, Candelise L. Antidepressant drugs for narcolepsy. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD003724. DOI: 10.1002/14651858.CD003724.pub3. DOI
- Alshaikh MK, Tricco AC, Tashkandi M, et al. Sodium oxybate for narcolepsy with cataplexy: systematic review and meta-analysis. J Clin Sleep Med 2012; 8: 451-8. pmid:22893778 PubMed
- Bjørn Bjorvatn, professor dr.med., Institutt for global helse og samfunnsmedisin, Universitetet i Bergen, og leder av Nasjonal kompetansetjeneste for søvnsykdommer, Haukeland Universitetssykehus
- Ingard Løge, spesialist allmennmedisin, redaktør NEL