Hjernemetastaser
Sist revidert:
Sist revidert av:Terje Johannessen
Definisjon:
Skyldes hematogen spredning av kreftsykdom til hjernen fra en primærtumor beliggende et annet sted i kroppen
Forekomst:
Ca. 10% av kreftpasientene utvikler i løpet av sykdommen hjernemetastaser
Symptomer:
Allminnelige kliniske manifestasjoner er nevrologiske utfallssymptomer, psykisk endring, hodepine, kvalme, oppkast og tretthet
Funn:
Kan være fokalnevrologiske utfall og tegn på økt intrakranielt trykk
Diagnostikk:
MR er den mest sensitive undersøkelsen til påvisning av små metastaser
Behandling:
Mulighetene er kirurgi, gammakniv ("strålekniv"), stereotaktisk strålebehandling, fullhjernebestråling, steroidbehandling, kjemoterapi
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- Mitchell DK, Kwon HJ, Kubica PA, Huff WX, O'Regan R, Dey M. Brain metastases: An update on the multi-disciplinary approach of clinical management. Neurochirurgie. 2022;68(1):69-85. PubMed
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- Sperduto PW, Kased N, Roberge D, et al. Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol. 2012;30(4):419-425. PubMed
- Terje Johannessen, professor i allmennmedisin, Trondheim
Tidligere fagmedarbeidere
- Tor Brommeland, dr. med., spesialist i nevrokirurgi ved Oslo Universitetssykehus Ullevål og Sørlandet Sykehus Kristiansand
- Espen Dietrichs, professor og avdelingsoverlege, Universitetet i Oslo og Nevrologisk avdeling, Rikshospitalet, Oslo
- Torstein R. Meling, dr. med., overlege, Nevrokirurgisk avdeling, Rikshospitalet, Oslo