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Hjernemetastaser

Sist revidert:
Sist revidert av:
Definisjon:
Skyldes hematogen spredning av kreftsykdom til hjernen fra en primærtumor beliggende et annet sted i kroppen
Forekomst:
Ca. 10% av kreftpasientene utvikler i løpet av sykdommen hjernemetastaser
Symptomer:
Allminnelige kliniske manifestasjoner er nevrologiske utfallssymptomer, psykisk endring, hodepine, kvalme, oppkast og tretthet
Funn:
Kan være fokalnevrologiske utfall og tegn på økt intrakranielt trykk
Diagnostikk:
MR er den mest sensitive undersøkelsen til påvisning av små metastaser
Behandling:
Mulighetene er kirurgi, gammakniv ("strålekniv"), stereotaktisk strålebehandling, fullhjernebestråling, steroidbehandling, kjemoterapi
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  2. Mitchell DK, Kwon HJ, Kubica PA, Huff WX, O'Regan R, Dey M. Brain metastases: An update on the multi-disciplinary approach of clinical management. Neurochirurgie. 2022;68(1):69-85. PubMed  
  3. Meling TR, Helseth E, Unsgård G, Nakstad PH, Wester K. Hjernemetastaser hos voksne. Tidsskr Nor Lægeforen 2005; 125: 2179-82. PubMed  
  4. Tong E, McCullagh KL, Iv M. Advanced Imaging of Brain Metastases: From Augmenting Visualization and Improving Diagnosis to Evaluating Treatment Response. Front Neurol. 2020;11:270. Published 2020 Apr 15. PMID: 32351445 PubMed  
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  10. Gagliardi F, De Domenico P, Snider S, et al. Role of stereotactic radiosurgery for the treatment of brain metastasis in the era of immunotherapy: A systematic review on current evidences and predicting factors. Crit Rev Oncol Hematol. 2021;165:103431. PubMed  
  11. Palmer JD, Klamer BG, Ballman KV, et al. Association of Long-term Outcomes With Stereotactic Radiosurgery vs Whole-Brain Radiotherapy for Resected Brain Metastasis: A Secondary Analysis of The N107C/CEC.3 (Alliance for Clinical Trials in Oncology/Canadian Cancer Trials Group) Randomized Clinical Trial. JAMA Oncol. Published online October 20, 2022. PMID: 36264568 PubMed  
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  13. Kim IY, Jung S, Jung TY, et al. Repeat Stereotactic Radiosurgery for Recurred Metastatic Brain Tumors. J Korean Neurosurg Soc. 2018;61(5):633-639. PubMed  
  14. Mehta MP, Paleologos NA, Mikkelsen T, et al. The role of chemotherapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan;96(1):71-83. Epub 2009 Dec 4. Review.PMID:19960229 PubMed  
  15. Kotecha R, Gondi V, Ahluwalia MS et al. Recent advances in managing brain metastasis. F1000 Res 2018; 7: 1772. PMID: 30473769 PubMed  
  16. Enrique GV, Irving SR, Ricardo BI et al. Diagnosis and management of brain metastases: an updated review from a radiation oncology perspective. J Cancer Metastasis Treat 2019; 5: 54. PubMed  
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  • Terje Johannessen, professor i allmennmedisin, Trondheim

Tidligere fagmedarbeidere

  • Tor Brommeland, dr. med., spesialist i nevrokirurgi ved Oslo Universitetssykehus Ullevål og Sørlandet Sykehus Kristiansand
  • Espen Dietrichs, professor og avdelingsoverlege, Universitetet i Oslo og Nevrologisk avdeling, Rikshospitalet, Oslo
  • Torstein R. Meling, dr. med., overlege, Nevrokirurgisk avdeling, Rikshospitalet, Oslo