Glaukoma simplex
Sist revidert:
Sist revidert av:Terje Johannessen
Definisjon:
En progressiv retinal nevropati der skade av ganglieceller og retinale aksoner i n. optikus gir skotomer og synsfeltsutfall. Årsak ukjent
Forekomst:
Global prevalens over 40 år er 3,5%
Symptomer:
Asymptomatisk lenge, men etter hvert oppstår tiltakende synsfeltsutfall
Funn:
Synsfeltsutfall, ekskavert papille - overstiger 2/3 av papillediameter, nasal forskyvning av retinale kar og hos ca. 75% forhøyet øyetrykk
Diagnostikk:
Utredes videre av øyelege
Behandling:
Individualiseres og består i medikamenter, laserterapi og/eller kirurgi
- Nasjonal behandlingstjeneste for medfødt glaukom, Oslo universitetssykehus HF, nettsted
- Gupta D. Glaucoma. Am Fam Physician. 2016 Apr 15;93(8):668-674.
- Bek T, et al. Simplex glaucom. Lægehåndbogen, sist oppdatert 25.04.2019.
- Jenssen F, Krefting E, Ulvik SO. Åpenvinkel glaukom. Norsk kvalitetshåndbok for oftalmologi, 2015. www.helsebiblioteket.no
- Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90(3):262–267.
- Tham Y-C, Li X, Wong TY, et al. Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040. Ophtalmology, Nov 2014; 121 (11) : 2081–2090 . pmid:10.1016/j.ophtha.2014.05.013
- Bell JA. Primary open-angle glaucoma. Medscape, last updated Feb 20, 2014. emedicine.medscape.com
- Bourne RR, Jonas JB, Flaxman, et al. Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe: 1990-2010. Br J Ophtalmol 2014. pmid:24665132 PubMed
- Kang JH, Boumenna T, Stein JD, et al. Association of Statin Use and High Serum Cholesterol Levels With Risk of Primary Open-Angle Glaucoma. JAMA Ophtalmlol 2019. pmid:31046067 PubMed
- Zhao D, Cho J, Kim MH, et al. Diabetes, fasting glucose, and the risk of glaucoma: a meta-analysis. Ophthalmology. 2015 ;122(1):72-8. doi: 10.1016/j.ophtha.2014.07.051.
- Kumar S, Giubilato A, Morgan W, et al. Glaucoma screening: analysis of conventional and telemedicine-friendly devices. Clin Experiment Ophthalmol. 2007;35(3):237–243.
- Jeong da W, Kook MS, Lee KS, Lee JR, Han S. Circadian pattern of intraocular pressure fluctuations in young myopic eyes with open-angle glaucoma. Invest Ophthalmol Vis Sci. 2014;55(4):2148–2156.
- Moyer VA, et al. Screening for glaucoma: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2013. doi:10.7326/0003-4819-159-6-201309170-00685 DOI
- Alexandrescu C, Dascalu AM, Panca A, et al. Confocal scanning laser ophthalmoscopy in glaucoma diagnosis and management. J Med Life. 2010;3(3):229-234. PubMed
- Kuang TM, Zhang C, Zangwill LM, et al. Estimating the lead time gained by optical coherence tomography in detecting glaucoma before development of visual field defects. Ophtalmology. Published Online: July 18, 2015 . doi:http://dx.doi.org/10.1016/j.ophtha.2015.06.015
- Springelkamp H, Lee K, Wolfs RC, et al. Population-based evaluation of retinal nerve fiber layer, retinal ganglion cell layer, and inner plexiform layer as a diagnostic tool for glaucoma. Invest Ophthalmol Vis Sci. 2014;55(12):8428–8438.
- Shih GC, Calkins DJ. Secondary neuroprotective effects of hypotensive drugs and potential mechanisms of action. Expert Rev Ophtalmol 2012; 7: 161-75. PubMed
- Maier PC, Funk J, Schwarzer G, Antes G, Falck-Ytter YT. Treatment of ocular hypertension and open angle glaucoma: meta-analysis of randomised controlled trials. BMJ 2005; 331: 134-6. British Medical Journal
- Kolko M. Present and New Treatment Strategies in the Management of Glaucoma. Open Ophthalmol J 2015; 9: 89-100. pmid:26069521 PubMed
- Saylor M, McLoon LK, Harrison AR, Lee MS. Experimental and clinical evidence for brimonidine as an optic nerve and retinal neuroprotective agent. Arch Ophtalmol 2009; 127: 402-6. PubMed
- Garway-Heath DF, Crabb DP, Bunce C, et al. Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial. Lancet. 2014 Dec 18.
- Li X, Wang W, Zhang X. Meta-analysis of selective laser trabeculoplasty versus topical medication in the treatment of open-angle glaucoma. BMC Ophthalmology (2015) 15:107 . doi:10.1186/s12886-015-0091-2 DOI
- Kirwan JF, Rennie C, Evans JR. Beta radiation for glaucoma surgery. Cochrane Database Syst Rev 2012; 6: CD003433. Cochrane (DOI)
- Terje Johannessen, professor i allmennmedisin, Trondheim
Tidligere fagmedarbeidere
- Johan H. Seland, professor emeritus, Universitetet i Bergen
- Knut A. Holtedahl, professor i allmennmedisin, Institutt for samfunnsmedisinske fag, Universitetet i Tromsø
- Toke Bek, prof., overlæge, dr. med, Øjenafdelingen, Aarhus Universitetshospital (Lægehåndbogen)