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Kortvoksthet, idiopatisk

Sist revidert:
Sist revidert av:


Definisjon:
Høyde < 2,5 percentilen i forhold til alder uten påvisbar sykdom
Forekomst:
Gutter henvises oftere enn jenter på grunn av denne problemstillingen. Ikke uvanlig tilstand
Symptomer:
Kortvokst uten andre tegn til sykdom
Funn:
Normal veksthastighet
Diagnostikk:
Blodprøver (hematologi, stoffskifte, IGF-1, IGFBP 3) skal være normale og det skal være normal respons på veksthormonstimulering
Behandling:
Veksthormon anbefales ikke
  1. Júlíusson PB, Bjørndalen H, Köpp UMS, Bjerknes R. Kortvoksthet og vekstretardasjon. Generell veileder i pediatri. Norsk barnelegeforening. Sist revidert 2019.
  2. Cohen P, Rogol AD, Deal CL, et al. Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop. J Clin Endocrinol Metab. 2008; 93: 4210-7. PubMed  
  3. Lee MM. Idiopathic short stature. N Engl J Med 2006; 354: 2576-82. New England Journal of Medicine  
  4. Gubitosi-Klug RA, Cuttler L. Idiopathic short stature. Endocrinol Metab Clin North Am 2005; 34: 565-80. PubMed  
  5. Albertsson-Wikland K, Aronson AS, Gustafsson J, et al. Dose-dependent effect of growth hormone on final height in children with short stature without growth hormone deficiency. J Clin Endocrinol Metab. 2008; 93: 4342-50. PubMed  
  6. Collett-Solberg PF, Misra M,. The role of recombinant human insulin-like growth factor-I in treating children with short stature. J Clin Endocrinol Metab. 2008; 93: 10-8. PubMed  
  7. Wit JM, Rekers-Mombarg LTM, Cutler GB, et al. Growth hormone (GH) treatment to final height in children with idiopathic short stature: evidence for a dose effect. J Pediatr 2005; 146: 45-53. PubMed  
  8. Grimberg A, Kutikov JK, Cucchiara AJ. Sex differences in patients referred for evaluation of poor growth. J Pediatr 2005; 146: 212. PubMed  
  9. Rosenfeld RG. The molecular basis of idiopathic short stature. Growth Horm IGF Res 2005; 15(Suppl A): S3-S5.
  10. Deodati A, Cianfarani S. Impact of growt hormone therapy on adult height of children with idiopathic short stature: systematic review. BMJ 2011; 342: c7157. BMJ (DOI)  
  11. Bryant J, Baxter L, Cave CB, Milne R. Recombinant growth hormone for idiopathic short stature in children and adolescents. Cochrane Database of Systematic Reviews 2007, Issue 3. Art. No.: CD004440. DOI: 10.1002/14651858.CD004440.pub2 DOI  
  12. Kemp SF, Kuntze J, Attie KM, et al. Efficacy and safety results of long-term growth hormone treatment of idiopathic short stature. J Clin Endocrinol Metab 2005; 90: 5247-53. PubMed  
  • Terje Johannessen, professor i allmennmedisin, Trondheim