Urinsyregikt
Sist revidert:
Sist revidert av:Till Uhlig
Definisjon:
En residiverende akutt artritt i perifere ledd som skyldes avleiring av uratkrystaller i eller rundt ledd og andre strukturer.
Forekomst:
1-2%, og forekomsten øker med alderen. Både forekomst og økning er størst blant menn
Symptomer:
Akutte, gjentatte anfall med artritt i stortåen, ev. ankel, andre ledd eller rundt sener
Funn:
Rødt, hovent ledd eller seneskjede. Ev. subkutane tofi over sener
Diagnostikk:
Urinsyre er oftest forhøyet, men ikke alltid, ev. også forhøyet CRP, SR og leukocytter
Behandling:
Akutte anfall behandles med kolkisin eller NSAID. Allopurinol, probenecid eller febuksostat brukes profylaktisk som urinsyrenedsettende medikasjon.Anbefales hjertediett
- Hui M, Carr A, Cameron S, et al. The British Society for Rheumatology Guideline for the management of gout. Rheumatology 2017; 56: e1–e20. doi.org
- Uhlig T, Halsan Liff M, Brække Norheim K, et al. Urinsyregikt (Arthritis urica). Veileder om urinsyregikt, Norsk Revmatologisk Forening, 07.09.2022. metodebok.no
- Bursill D, Taylor WJ, Terkeltaub R, et al. Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout. Ann Rheum Dis. 2019 Nov;78(11):1592-1600. Epub 2019 Sep 9. PMID: 31501138. PubMed
- Clebak KT, Morrison A Croad JR. Gout: Rapid Evidence Review. Am Fam Physician 2020 Nov 1;102(9):533-538. PubMed
- Kapetanovic MC, Hameed M, Turkiewicz A, et al. Prevalence and incidence of gout in southern Sweden from the socioeconomic perspective. RMD Open. 2016 Nov 1;2(2):e000326. PMID: 27933209. PubMed
- Singh JA, Reddy SG, Kundukulam J. Risk factors for gout and prevention: a systematic review of the literature. Curr Opin Rheumatol. 2011;23(2):192–202. PMID: 21285714. PubMed
- Kuo CF, Grainge MJ, Mallen C, et al. Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study. Ann Rheum Dis. 2015;74(4):661–667. PMID: 24431399. PubMed
- Choi HK, Willett W, Curhan G. Fructose-rich beverages and risk of gout in women. JAMA 2010; 304: 2270-8. pmid: 21068145 PubMed
- Richette P, Doherty M, Pascual E, Barskova V, Becce F, Castaneda J, et al. 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout. Ann Rheum Dis. 2020;79(1):31-8. PubMed
- Richette P, Doherty M, Pascual E, et al. 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout. Ann Rheum Dis 2019 PMID: 31167758 PubMed
- Janssens HJ, Fransen J, van de Lisdonk EH, et al. A diagnostic rule for acute gouty arthritis in primary care without joint fluid analysis. Arch Intern Med 2010; 170: 1120-6. pmid:20625017 PubMed
- Uhlig T, Eskild T, Hammer HB. Urinsyregikt – nytt innen diagnostikk og behandling. Tidsskr Nor Lægeforen 2016; 136: 1804-7. doi:10.4045/tidsskr.16.0147 DOI
- Dalbeth N, Kalluru R, Aati O, et al. Tendon involvment in the feet of patients with gout: a dual-energy CT study. Ann Rheum Dis 2013; 72: 1545-8. pmid: 23334212 PubMed
- Gaffo AL. Clinical manifestations and diagnosis of gout. UpToDate, last updated May 19, 2023. UpToDate
- Qaseem A, McLean RM, Starkey M, et al. Diagnosis of acute gout: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2017;166(1):52–57. PMID: 27802479.
- van Durme CM, Wechalekar MD, Buchbinder R, et al. Non-steroidal anti-inflammatory drugs for acute gout. Cochrane Database Syst Rev 2014; 9: CD010120. pmid:25225849 PubMed
- Roddy E, Clarkson K, Blagojevic-Bucknall M, et al. Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care. Ann Rheum Dis. 2019. PMID: 31666237 PubMed
- Bongartz T, Glazebrook KN, Kavros SJ, et al. Dual-energy CT for the diagnosis of gout: an accuracy and diagnostic yield study. Ann Rheum Dis 2014. pmid: 24671771 PubMed
- Bursill D, Taylor WJ, Terkeltaub R, et al. Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout. Ann Rheum Dis. 2019;78(11):1592-600. PubMed
- Sivera F, Andres M, Carmona L, et al. Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative. Ann Rheum Dis 2013. pmid: 23868909 PubMed
- Vinik O, Wechalekar MD, Falzon L, et al. Treatment of asymptomatic hyperuricemia for the prevention of gouty arthritis, renal disease, and cardiovascular events: a systematic literature review. J Rheumatol Suppl. 2014;92:70-4. pmid: 23024028 PubMed
- Juraschek SP, Gelber AC, Choi HK. Effects of the Dietary Approaches to Stop Hypertension (DASH) Diet and Sodium Intake on Serum Uric Acid. Arthritis Rheumatol 2016; 68: 3002-9. pmid:27523583 PubMed
- Khanna D, Fitzgerald JD, Khanna PP, et al; American College of Rheumatology. 2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken) 2012;64:1431-1446. PubMed
- Richette P, Doherty M, Pascual E, et al. 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis. 2016. PMID: 27457514 PubMed
- Neoqi T, Chen C, Niu J et al. Alcohol quantity and type on risk of recurrent gout attacks: An internet-based case-crossover study. Am J Med, published online 21 January 2014. pmid: 24440541 PubMed
- Terkeltaub RA, Furst DE, Bennett K, et al. High versus low dosing of oral colchicine for early acute gout flare: twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study. Arthritis Rheum. 2010;62(4):1060–1068. PMID: 20131255. PubMed
- Zhang S, Zhang Y, Liu P, et al. Efficacy and safety of etoricoxib compared with NSAIDs in acute gout: a systematic review and a meta-analysis. Clin Rheumatol. 2016 Jan;35(1):151-8. Epub 2015 Jun 24. pmid: 26099603 PubMed
- Billy CA;Lim RT;Ruospo M;Palmer SC;Strippoli GFM. Corticosteroid or Nonsteroidal Antiinflammatory Drugs for the Treatment of Acute Gout: A Systematic Review of Randomized Controlled Trials. J Rheumatol. 2017 Aug 1. pii: jrheum.170137. (Review) PMID: 28765243 PubMed
- Rainer TH, Cheng CH, Janssens HJ, et al. Oral prednisolone in the treatment of acute gout: A pragmatic, multicenter, double-blind, randomized trial. Ann Intern Med 2016. pmid: 26903390 PubMed
- Zhang YK, Yang H, Zhang JY, et al. Comparison of intramuscular compound betamethasone and oral diclofenac sodium in the treatment of acute attacks of gout. Int J Clin Pract. 2014 Jan 29. pmid: 24472084 PubMed
- Dalbeth N, Merriman TR, Stamp LK.Gout.Lancet. 2016 Oct 22;388(10055):2039-2052. Epub 2016 Apr 21.PMID:27112094. PubMed
- Liew JW, Gardner GC. Use of Anakinra in Hospitalized Patients with Crystal-associated Arthritis. J Rheumatol 2019; 46: 1345-9. pmid:30647192 PubMed
- McCormick N, Yokose C, Wei J, et al. Comparative Effectiveness of Sodium-Glucose Cotransporter-2 Inhibitors for Recurrent Gout Flares and Gout-Primary Emergency Department Visits and Hospitalizations : A General Population Cohort Study. Ann Intern Med. 2023 Jul 25. doi: 10.7326/M23-0724. Epub ahead of print. PMID: 37487215. PubMed
- Richette P, Doherty M, Pascual E, et al. 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis. 2017 Jan;76(1):29-42. doi: 10.1136/annrheumdis-2016-209707. Epub 2016 Jul 25. PMID: 27457514. PubMed
- Kiltz U, Smolen J, Bardin T, et al. Treat-to-target (T2T) recommendations for gout. Ann Rheum Dis 2016. pmid:27658678 PubMed
- Taylor TH, Mecchella JN, Larson RJ et al. Initiation of allopurinol at first medical contact for acute attacks of gout: a randomized clinical trial. Am J Med 2012; 125: 1126-34. pmid:23098865 PubMed
- Seth R, Kydd AS, Buchbinder R, et al. Allopurinol for chronic gout. Cochrane Database Syst Rev. 2014 Oct 14;10. pmid: 25314636 PubMed
- Stamp LK, Taylor WJ, Jones PB et al. Starting dose is a risk factor for allopurinol hypersensitivity syndrome: A proposed safe starting dose of allopurinol. Arthritis Rheum 2012; 64: 2529-36. PubMed
- Tien YY, Shih MC, Tien CP, Huang HK, Tu YK. To Treat or Not to Treat? Effect of Urate-Lowering Therapy on Renal Function, Blood Pressure and Safety in Patients with Asymptomatic Hyperuricemia: A Systematic Review and Network Meta-Analysis. J Am Board Fam Med. 2022;35(1):140-151. PubMed
- Voelker R. Another Warning for Febuxostat. JAMA. 2019;321(13):1245. doi:10.1001/jama.2019.3043 DOI
- White WB, Saag KG, Becker MA, et al. Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout. N Engl J Med 2018;378(13):1200-10. New England Journal of Medicine
- O'Dell JR, Brophy MT, Pillinger MH, et al. Comparative Effectiveness of Allopurinol and Febuxostat in Gout Management. N Engl J Med 2022. doi:10.1056/EVIDoa2100028 DOI
- MacKenzie IS, Ford I, Nuki G, et al. Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial. Lancet 2020. pmid:33181081 PubMed
- Lim SY, Lu N, Choi HK. Septic arthritis in gout patients: a population-based cohort study. Rheumatology (Oxford) 2015; 54: 2095-9. PMID: 26170377 PubMed
- Hong J-Y, Lan T-Y, Tang G-J, et al. Gout and the risk of dementia. Arthritis Res Ther 2015;17: 139. PMID: 26018424. PubMed
- Shahin L, Patel KM, Heydari MK, Kesselman MM. Hyperuricemia and Cardiovascular Risk. Cureus. 2021;13(5):e14855. Published 2021 May 5. PMID: 34104597 PubMed
- Huang W-S, Lin C-L, Tsai C-H, Chang K-H. Association of gout with CAD and effect of antigout therapy on CVD risk among gout patients. J Inestig Med 2020; 68: 972-9. pmid:32098832 PubMed
- Chen J-H, Lan J-L, Cheng C-F, et al. Effect of Urate-lowering Therapy on the Risk of Cardiovascular Disease and All-cause Mortality in Patients with Gout: A Case-matched Cohort Study. J Rheumatol 2015; 42: 1694-1701. pmid: 26077411 PubMed
- Sultan AA, Muller S, Whittle R et al. Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy. CMAJ 2019; 191: E597-E603. pmid:31160496 PubMed
- Cipolletta E, Tata LJ, Nakafero G, Avery AJ, Mamas MA, Abhishek A. Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout. JAMA. 2022 Aug 2;328(5):440-450. PMID: 35916846. PubMed
- Uhlig T, Karoliussen LF, Sexton J, Borgen T, Haavardsholm EA, Kvien TK, Hammer HB. 12-month results from the real-life observational treat-to-target and tight-control therapy NOR-Gout study: achievements of the urate target levels and predictors of obtaining this target. RMD Open. 2021 Mar;7(1):e001628. PMID: 33782189. PubMed
- Doherty M, Jenkins W, Richardson H, et al. Efficacy and cost-effectiveness of nurse-led care involving education and engagement of patients and a treat-to-target urate-lowering strategy versus usual care for gout: a randomised controlled trial. Lancet. 2018 Oct 20;392(10156):1403-1412. PMID: 30343856. PubMed
- Uhlig T, Karoliussen LF, Sexton J, Kvien TK, Haavardsholm EA, Perez-Ruiz F, Hammer HB. One- and 2-year flare rates after treat-to-target and tight-control therapy of gout: results from the NOR-Gout study. Arthritis Res Ther. 2022 Apr 20;24(1):88. PMID: 35443675.
- Singh JA, Uhlig T. Chasing crystals out of the body: will treat to serum urate target for gout help us get there?. Ann Rheum Dis 2017; 76: 629-31. pmid:28031165 PubMed
- Dalbeth N, Stamp L. Hyperuricaemia and gout: time for a new staging system?. Ann Rheum Dis 2014; 73: 1598-600. pmid:24718961 PubMed
- Till Uhlig, professor i revmatologi, Klinikk for revmatologi, poliklinikk og forskning, Diakonhjemmet sykehus, og Universitetet i Oslo
- Tor Andre Johannessen, lege og redaktør NEL (tilpasning til NEL)
Tidligere fagmedarbeidere
- John Cooper, spesialist i allmennmedisin og indremedisin, Medisinsk avdeling, Sentralsjukehuset i Rogaland, Stavanger
- Even Lærum, professor i allmennmedisin, Institutt for samfunnsmedisinske fag, Universitetet i Oslo