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Hypertriglyseridemi

Hypertriglyseridemi er en tilstand med forhøyede triglyseridverdier i blodet og regnes som en risikofaktor for hjerte- og karsykdom. Triglyserider utgjør en viktig del av fettstoffene (lipidene) som sirkulerer i blodet.

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https://nhi.no/sykdommer/hormoner-og-naring/kolesterol-og-fett/hypertriglyseridemi/ 

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Referanser

Dette dokumentet er basert på det profesjonelle dokumentet Hypertriglyseridemi. Referanselisten for dette dokumentet vises nedenfor.

  1. Brunzell JD. Hypertriglyceridemia. N Engl J Med 2007; 357: 1009-17. PubMed 
  2. Kushner PA, Cobble ME. Hypertriglyceridemia: the importance of identifying patients at risk. Postgrad Med. 2016 Nov;128(8):848-58. PubMed 
  3. Leaf DA. Hypertriglyceridaemia. BMJ Best Practice, last updated May 2018. bestpractice.bmj.com 
  4. Sweeney MET. Hypertriglyceridemia. Medscape. Last updated May 30, 2014. http://emedicine.medscape.com/article/126568-overview.
  5. Tontstad S. Ny forståelse av hypertriglyseridemi og hjerte- og karsykdom. Indremedisineren, 26.10.2018. indremedisineren.no 
  6. Beigneux AP, Miyashita K, Ploug M, et al. Autoantibodies against GPIHBP1 as a cause of hypertriglyceridemia. N Engl J Med 2017: 376:1647-58. doi: 10.1056/NEJMoa1611930 DOI 
  7. Oh RC, Trivette ET, Westerfield KL. Management of Hypertriglyceridemia: Common Questions and Answers. Am Fam Physician. 2020;102(6):347-354. PubMed 
  8. Miller M, Stone NJ, Ballantyne C, et al. Triglycerides and cardiovascular disease: A scientific statement from the American Heart Association. Circulation 2011; 123: 2292-333. Circulation 
  9. Nordestgaard BG, Varbo A. Triglycerides and cardiovascular disease. Lancet. 2014 ;384(9943):626-35. doi: 10.1016/S0140-6736(14)61177-6 DOI 
  10. Di Angelantonio E, Sarwar N, Perry P, et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009;302(18):1993–2000. PMID: 19903920 PubMed 
  11. Zambon A, Brown BG, Deeb SS, Brunzell JD. Genetics of apolipoprotein B and apolipoprotein AI and premature coronary artery disease. J Intern Med 2006; 259: 473-80. PubMed 
  12. Khera AV, Won H-H, Peloso GM, et al. Association of rare and common variation in the lipoprotein lipase gene with coronary artery disease. JAMA 2017; 317: 937-46. doi: 10.1001/jama.2017.0972 DOI 
  13. Mach F, Baigent C, Catapano CL, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS). Eur Heart J 2020; 41: 111-188. pmid:31591002 PubMed 
  14. Bhatt DL, Steg PG, Miller M, et al; REDUCE-IT Investigators. Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia. N Engl J Med 2019; 380: 11-22. pmid:30415628 PubMed 
  15. Stroes ESG, Susekov AV, de Bruin TWA, et al. Omega-3 carboxylic acids in patients with severe hypertriglyceridemia: EVOLVE II, a randomized, placebo-controlled trial. J Clin Lipidol 2018; 12: 321-330. pmid:29289538 PubMed 
  16. Skulas-Ray AC, Wilson PWF, Harris WS, et al. Omega-3 Fatty Acids for the Management of Hypertriglyceridemia A Science Advisory From the American Heart Association. Circulation 2019. doi:10.1161/CIR.0000000000000709 DOI 
  17. Karlson BW, Palmer MK, Nicholls SJ et al. A Voyager meta-analysis of the impact of statin therapy on low-density lipoprotein cholesterol and triglyseride levels in patients with hypertriglyceridemia. Am J Cardiol 2016; 117: 1444-8. PubMed 
  18. Madsen CM, Varbo A, Nordestgaard BG. Unmet need for primary prevention in individuals with hypertriglyceridaemia not eligible for statin therapy according to European Society of Cardiology/European Atherosclerosis Society guidelines: a contemporary population-based study. Eur Heart J. 2018;39(7):610-619. PubMed 
  19. Freiberg JJ, Tybjærg-Hansen A, Jensen JS, Nordestgaard BG. Nonfasting triglycerides and risk of ischemic stroke in the general population. JAMA 2008; 300: 2142-52. Journal of the American Medical Association 
  20. Mozafarrian D, Maki KC, Bays HE, et al. Effectiveness of a Novel ω-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia A Randomized Clinical Trial. JAMA Netw Open 2022. doi:10.1001/jamanetworkopen.2021.41898 DOI 
  21. Stone NJ, Bilek S, Rosenbaum S. Recent National Cholesterol Education Program Adult Treatment Panel III update: adjustments and options. Am J Cardiol 2005; 96: 53-9. PubMed 
  22. Aung T, Halsey J, Kromhout D, et al. Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks: Meta-analysis of 10 Trials Involving 77 917 Individuals. JAMA Cardiol. 2018;3(3):225-234. PubMed